Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease.
Component of bee venom
SK channels
apamin
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
19 03 2020
19 03 2020
Historique:
received:
06
02
2020
revised:
15
03
2020
accepted:
17
03
2020
entrez:
25
3
2020
pubmed:
25
3
2020
medline:
6
3
2021
Statut:
epublish
Résumé
Bee venom is a natural toxin produced by honeybees and plays an important role in defending bee colonies. Bee venom has several kinds of peptides, including melittin, apamin, adolapamine, and mast cell degranulation peptides. Apamin accounts for about 2%-3% dry weight of bee venom and is a peptide neurotoxin that contains 18 amino acid residues that are tightly crosslinked by two disulfide bonds. It is well known for its pharmacological functions, which irreversibly block Ca2+-activated K+ (SK) channels. Apamin regulates gene expression in various signal transduction pathways involved in cell development. The aim of this study was to review the current understanding of apamin in the treatment of apoptosis, fibrosis, and central nervous system diseases, which are the pathological processes of various diseases. Apamin's potential therapeutic and pharmacological applications are also discussed.
Identifiants
pubmed: 32204567
pii: toxins12030195
doi: 10.3390/toxins12030195
pmc: PMC7150898
pii:
doi:
Substances chimiques
Bee Venoms
0
Cytokines
0
Potassium Channels, Calcium-Activated
0
Apamin
24345-16-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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