A multiscale modelling study on the sense and nonsense of thermal conductivity enhancement of liquid chromatography packings and other potential solutions for viscous heating effects.
Computational fluid dynamics
Core-shell particles
High pressure
Thermal conductivity
UHPLC
Viscous heating
Journal
Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488
Informations de publication
Date de publication:
07 Jun 2020
07 Jun 2020
Historique:
received:
29
11
2019
revised:
05
03
2020
accepted:
07
03
2020
pubmed:
25
3
2020
medline:
8
7
2020
entrez:
25
3
2020
Statut:
ppublish
Résumé
We report on a numerical study of the thermal conductivity and temperature distribution in analytical packed bed and monolithic HPLC columns to assess the feasibility of a number of potential solutions to the viscous heating problem that would normally impede high efficiency separations when moving to extreme operating pressures (e.g., 2500 bar). Computational fluid dynamic (CFD) simulations were employed to study heat transfer on three hierarchical levels of the column: meso‑pore level, through-pore level and column level. At the first level, realistic values were determined for the conductivity of the porous zone (k
Identifiants
pubmed: 32204881
pii: S0021-9673(20)30238-7
doi: 10.1016/j.chroma.2020.461022
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
461022Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.