Immunologic dysfunction contributes to the otitis prone condition.
Acute otitis media
Adaptive immunity
Antibody
Antigen presenting cells
B cells
CD4+ T cells
Haemophilus influenzae
Innate immunity
Moraxella catarrhalis
Otitis prone
Streptococcus pneumoniae
Journal
The Journal of infection
ISSN: 1532-2742
Titre abrégé: J Infect
Pays: England
ID NLM: 7908424
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
28
10
2019
revised:
12
03
2020
accepted:
15
03
2020
pubmed:
25
3
2020
medline:
19
3
2021
entrez:
25
3
2020
Statut:
ppublish
Résumé
Acute Otitis Media (AOM) is a multifactorial disease occurring mostly in young children who are immunologically naïve to AOM pathogens. This review focuses on work from Rochester NY, USA over the past 12 years among young children who had AOM infections microbiologically-confirmed by tympanocentesis, so called "stringently-defined". Among stringently-defined otitis prone children deficiencies in fundamental immune defense mechanisms have been identified that contribute to the propensity of young children to experience recurrent AOM. Dysfunction in innate immune responses that cause an immunopathological impact in the nasopharynx have been discovered including inadequate proinflammatory cytokine response and poor epithelial cell repair. Adaptive immunity defects in B cell function and immunologic memory resulting in low levels of antibody to otopathogen-specific antigens allows repeated infections. CD4+ and CD8+ T cell function and memory defects significantly contribute. The immune profile of an otitis prone child resembles that of a neonate through the first year of life. Immunologic deficits in otitis prone children cause them to be unusually vulnerable to viral upper respiratory infections and respond inadequately to routine pediatric vaccines.
Identifiants
pubmed: 32205139
pii: S0163-4453(20)30147-X
doi: 10.1016/j.jinf.2020.03.017
pmc: PMC7234916
mid: NIHMS1578555
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
614-622Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC008671
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.
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