Effects of Hypoxic and Ischemic Clinical Conditions on the Outcomes of Acute Ischemic Stroke Patients.

Acute ischemic stroke Hypoxic conditioning Ischemic conditioning

Journal

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

ISSN: 0972-5229

Titre abrégé: Indian J Crit Care Med

Pays: India

ID NLM: 101208863

Informations de publication

Date de publication:
Feb 2020

Historique:

entrez: 25 3 2020

pubmed: 25 3 2020

medline: 25 3 2020

Statut: ppublish

Résumé

Several studies have shown the neuroprotective role afforded by hypoxic and ischemic preconditioning in cerebrovascular disorders. There are several clinical conditions which simulate the hypoxic and ischemic conditioning in humans. The aim of this retrospective study is to identify whether the presence of any clinical scenarios mimicking the hypoxic and ischemic conditions prior to the current acute ischemic stroke (AIS) has a neuroprotective role in these patients. Data were collected for patients >18 years of age who underwent endovascular treatment for AIS from January 2009 to June 2015. A good outcome was defined as modified Rankin score (mRS) of 0 to 3 at discharge and a poor outcome as mRS of 4-6. A logistic regression analysis was performed to identify independent predictors of outcomes at discharge in both groups. A A total of 102 patients, aged 67 ± 16 years with median preprocedural National Institute of Health Stroke Scale (NIHSS) score 17.5 (1-36), were included. Twenty-one (21%) patients had a good outcome (mRS: 0-3) and 81 (79%) had a poor outcome (mRS: 4-6). A logistic regression analysis identified higher NIHSS score [odds ratio (OR): 1.251, confidence interval (CI): 1.11-1.40, Our data suggest that the occurrence of TIA preceding an AIS may be associated with the poor outcomes in patients with AIS, although this finding needs confirmation in larger studies. Athiraman U, Tempelhoff R, Karanikolas M. Effects of Hypoxic and Ischemic Clinical Conditions on the Outcomes of Acute Ischemic Stroke Patients. Indian J Crit Care Med 2020;24(2):104-108.

Sections du résumé

BACKGROUND BACKGROUND

MATERIALS AND METHODS METHODS

Data were collected for patients >18 years of age who underwent endovascular treatment for AIS from January 2009 to June 2015. A good outcome was defined as modified Rankin score (mRS) of 0 to 3 at discharge and a poor outcome as mRS of 4-6. A logistic regression analysis was performed to identify independent predictors of outcomes at discharge in both groups. A

RESULTS RESULTS

A total of 102 patients, aged 67 ± 16 years with median preprocedural National Institute of Health Stroke Scale (NIHSS) score 17.5 (1-36), were included. Twenty-one (21%) patients had a good outcome (mRS: 0-3) and 81 (79%) had a poor outcome (mRS: 4-6). A logistic regression analysis identified higher NIHSS score [odds ratio (OR): 1.251, confidence interval (CI): 1.11-1.40,

CONCLUSION CONCLUSIONS

Our data suggest that the occurrence of TIA preceding an AIS may be associated with the poor outcomes in patients with AIS, although this finding needs confirmation in larger studies.

HOW TO CITE THIS ARTICLE UNASSIGNED

Athiraman U, Tempelhoff R, Karanikolas M. Effects of Hypoxic and Ischemic Clinical Conditions on the Outcomes of Acute Ischemic Stroke Patients. Indian J Crit Care Med 2020;24(2):104-108.

Identifiants

DOI: 10.5005/jp-journals-10071-23349 PMID: 32205941 PMC: PMC7075063

pubmed: 32205941

doi: 10.5005/jp-journals-10071-23349

pmc: PMC7075063

doi:

Types de publication

Journal Article

Langues

eng

Pagination

104-108

Subventions

Organisme : NIGMS NIH HHS

ID : T32 GM108539

Pays : United States

Informations de copyright

Déclaration de conflit d'intérêts

Source of support: Nil Conflict of interest: None

Références

Prog Neurobiol. 2014 Mar;114:58-83

pubmed: 24389580

Neurosci Lett. 2005 Apr 4;377(3):206-11

pubmed: 15755527

Psychiatry Clin Neurosci. 2008 Dec;62(6):705-12

pubmed: 19068008

Ann N Y Acad Sci. 2003 May;993:168-78; discussion 195-6

pubmed: 12853311

Ann Clin Transl Neurol. 2015 Apr;2(4):325-37

pubmed: 25909079

Stroke. 1995 Aug;26(8):1348-52

pubmed: 7631335

Lancet. 2005 Jul 2-8;366(9479):29-36

pubmed: 15993230

Lancet Neurol. 2009 Apr;8(4):398-412

pubmed: 19296922

Stroke. 1994 Dec;25(12):2384-90

pubmed: 7974577

Eur Rev Med Pharmacol Sci. 2016 Dec;20(24):5164-5167

pubmed: 28051252

Exp Biol Med (Maywood). 2017 Jun;242(11):1198-1206

pubmed: 28585890

Clin Neurol Neurosurg. 2013 Oct;115(10):2124-9

pubmed: 23958050

Eur J Neurol. 2008 Aug;15(8):797-801

pubmed: 18505406

Exp Neurol. 2015 Oct;272:26-40

pubmed: 25900056

Arch Med Sci. 2017 Aug;13(5):1057-1061

pubmed: 28883846

Front Physiol. 2012 Feb 20;3:27

pubmed: 22363297

Eur Neurol. 2016;76(5-6):278-283

pubmed: 27794566

Acta Neurobiol Exp (Wars). 2005;65(2):213-20

pubmed: 15960309

Brain Res. 2001 Mar 23;895(1-2):59-65

pubmed: 11259760

Crit Care Med. 2015 Aug;43(8):1654-9

pubmed: 25978337

Lancet Neurol. 2009 Jan;8(1):48-56

pubmed: 19058760

Sleep Med Rev. 2015 Apr;20:27-45

pubmed: 25155182

J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):659-60

pubmed: 15026523

Neurology. 2000 Jun 13;54(11):2089-94

pubmed: 10851368

Stroke. 2017 May;48(5):1412-1415

pubmed: 28265014

Stroke. 1999 Sep;30(9):1851-4

pubmed: 10471435

J Stroke Cerebrovasc Dis. 2008 Sep;17(5):257-62

pubmed: 18755403

J Cereb Blood Flow Metab. 2003 Dec;23(12):1448-54

pubmed: 14663340

J Stroke Cerebrovasc Dis. 2013 Apr;22(3):260-6

pubmed: 22005036

Eur Neurol. 2011;66(5):265-70

pubmed: 21997607

Cerebrovasc Dis. 2004;18(4):304-11

pubmed: 15331877