DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues.
DNA methylation
atherosclerotic plaque
epigenetics
matrix metalloproteinases
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
10 Mar 2020
10 Mar 2020
Historique:
received:
09
10
2019
accepted:
13
01
2020
entrez:
25
3
2020
pubmed:
25
3
2020
medline:
25
3
2020
Statut:
epublish
Résumé
Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while no studies of DNA methylation (DNAm) patterns of We profiled the DNAm status of stable and ulcerated atherosclerotic plaques obtained as pair sets from three patients who underwent carotid endarterectomy surgery. We selected 415 CpG sites, mapping into Three CpG sites were statistically significantly associated with unstable plaque portions; cg02969624, The results suggest different DNAm status of MMP24 between stable and unstable atherothrombotic carotid plaques, and between atherothrombotic stroke and controls in blood samples.
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while no studies of DNA methylation (DNAm) patterns of
METHODS
METHODS
We profiled the DNAm status of stable and ulcerated atherosclerotic plaques obtained as pair sets from three patients who underwent carotid endarterectomy surgery. We selected 415 CpG sites, mapping into
RESULTS
RESULTS
Three CpG sites were statistically significantly associated with unstable plaque portions; cg02969624,
CONCLUSIONS
CONCLUSIONS
The results suggest different DNAm status of MMP24 between stable and unstable atherothrombotic carotid plaques, and between atherothrombotic stroke and controls in blood samples.
Identifiants
pubmed: 32206187
doi: 10.18632/oncotarget.27469
pii: 27469
pmc: PMC7075467
doi:
Types de publication
Journal Article
Langues
eng
Pagination
905-912Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST The authors have no conflicts of interest to declare.
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