Role of Opioid System in Empathy-like Behaviours in Rats.
Anxiety
Empathy
Morphine
Rats
Journal
Addiction & health
ISSN: 2008-4633
Titre abrégé: Addict Health
Pays: Iran
ID NLM: 101582275
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
entrez:
25
3
2020
pubmed:
25
3
2020
medline:
25
3
2020
Statut:
ppublish
Résumé
Empathy is defined as the ability to simulate the mental states of others. Recent studies have demonstrated empathy-like behaviors in other animals including rats and mice. The objective of the current study was to evaluate the effect of acute administration of morphine and naloxone on cognition and nociception changes following observing conspecifics undergoing nociceptive stimulus. Adult male Wistar rats were used (n = 8 for each group). One cagemate received formalin injection into the hindpaw five times within a nine-day period and the other cagemate observed the pain while being pretreated with saline, morphine, or naloxone [10 mg/kg, intraperitoneal (i.p.)]. Pain behaviors, anxiety-like behaviour, locomotion, balance and muscle strength were evaluated in the observer animals. Observing a cagemate in pain increased anxiety-like behavior and reduced thermal pain threshold in the observer animals. Administration of morphine reversed these effects and naloxone did not affect the responses. Results of the current study reveal an important role for opioid receptors (ORs) in empathy for pain, so that activation of this system dampens the empathy-like responses.
Sections du résumé
BACKGROUND
BACKGROUND
Empathy is defined as the ability to simulate the mental states of others. Recent studies have demonstrated empathy-like behaviors in other animals including rats and mice. The objective of the current study was to evaluate the effect of acute administration of morphine and naloxone on cognition and nociception changes following observing conspecifics undergoing nociceptive stimulus.
METHODS
METHODS
Adult male Wistar rats were used (n = 8 for each group). One cagemate received formalin injection into the hindpaw five times within a nine-day period and the other cagemate observed the pain while being pretreated with saline, morphine, or naloxone [10 mg/kg, intraperitoneal (i.p.)]. Pain behaviors, anxiety-like behaviour, locomotion, balance and muscle strength were evaluated in the observer animals.
FINDINGS
RESULTS
Observing a cagemate in pain increased anxiety-like behavior and reduced thermal pain threshold in the observer animals. Administration of morphine reversed these effects and naloxone did not affect the responses.
CONCLUSION
CONCLUSIONS
Results of the current study reveal an important role for opioid receptors (ORs) in empathy for pain, so that activation of this system dampens the empathy-like responses.
Identifiants
pubmed: 32206214
doi: 10.22122/ahj.v11i4.243
pii: AHJ-11-216
pmc: PMC7073811
doi:
Types de publication
Journal Article
Langues
eng
Pagination
216-222Informations de copyright
© 2019 Kerman University of Medical Sciences.
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