Correlation among the Behavioral Features in the Offspring of Morphine-Abstinent Rats.

Administration Behavior Correlation of data Epigenomics Morphine Oral

Journal

Addiction & health
ISSN: 2008-4633
Titre abrégé: Addict Health
Pays: Iran
ID NLM: 101582275

Informations de publication

Date de publication:
Oct 2019
Historique:
entrez: 25 3 2020
pubmed: 25 3 2020
medline: 25 3 2020
Statut: ppublish

Résumé

Critical analysis of new evidence in medical sciences relies on statistics in terms of correlation. The aim of the present study was to evaluate the correlation coefficients among the behavioral features in the offspring of morphine-abstinent parent(s). The offspring of rats with various parental morphine-exposure were divided into four groups including offspring with healthy parents (CTL), offspring with paternal morphine-abstinent (PMA) parent, offspring with maternal morphine-abstinent (MMA) parent, and offspring with both morphine-abstinent (BMA) parents. Pain perception, depression-like behavior and avoidance-memory in the offspring were quantified. The association between variables was measured using Pearson correlation analysis. A strong correlation was observed between pain and depressive-like behavior in female and male offspring of healthy parents. Moreover, in the male and female offspring of healthy parents and BMA, no significant correlation was observed between avoidance memory and pain behavior or depressive-like behavior. However, in the offspring of MMA, a strong correlation was observed between avoidance memory and depressive-like behavior. The results revealed that in comparison with the offspring with CTL, the correlation among the behavioral futures in the offspring with MMA or PMA parents is significantly different.

Sections du résumé

BACKGROUND BACKGROUND
Critical analysis of new evidence in medical sciences relies on statistics in terms of correlation. The aim of the present study was to evaluate the correlation coefficients among the behavioral features in the offspring of morphine-abstinent parent(s).
METHODS METHODS
The offspring of rats with various parental morphine-exposure were divided into four groups including offspring with healthy parents (CTL), offspring with paternal morphine-abstinent (PMA) parent, offspring with maternal morphine-abstinent (MMA) parent, and offspring with both morphine-abstinent (BMA) parents. Pain perception, depression-like behavior and avoidance-memory in the offspring were quantified. The association between variables was measured using Pearson correlation analysis.
FINDINGS RESULTS
A strong correlation was observed between pain and depressive-like behavior in female and male offspring of healthy parents. Moreover, in the male and female offspring of healthy parents and BMA, no significant correlation was observed between avoidance memory and pain behavior or depressive-like behavior. However, in the offspring of MMA, a strong correlation was observed between avoidance memory and depressive-like behavior.
CONCLUSION CONCLUSIONS
The results revealed that in comparison with the offspring with CTL, the correlation among the behavioral futures in the offspring with MMA or PMA parents is significantly different.

Identifiants

DOI: 10.22122/ahj.v11i4.253 PMID: 32206219 PMC: PMC7073814
pubmed: 32206219
doi: 10.22122/ahj.v11i4.253
pii: AHJ-11-262
pmc: PMC7073814
doi:

Types de publication

Journal Article

Langues

eng

Pagination

262-275

Informations de copyright

© 2019 Kerman University of Medical Sciences.

Références

Int J Dev Neurosci. 2018 Oct;69:49-59
pubmed: 29966738
Pain Physician. 2010 Sep-Oct;13(5):401-35
pubmed: 20859312
Pain. 1985 Dec;23(4):375-80
pubmed: 4088698
Neurosci Lett. 2012 Aug 1;522(2):128-33
pubmed: 22732446
Science. 2004 May 7;304(5672):881-3
pubmed: 15131309
Phys Ther. 2016 Jul;96(7):1049-56
pubmed: 26700272
Br J Psychiatry Suppl. 1996 Jun;(30):101-8
pubmed: 8864155
Aging Ment Health. 2007 Nov;11(6):708-15
pubmed: 18074258
Biol Psychiatry. 2004 Nov 15;56(10):714-7
pubmed: 15556111
Ann Fam Med. 2012 Jul-Aug;10(4):304-11
pubmed: 22778118
Drug Alcohol Depend. 2006 Jun;83 Suppl 1:S4-7
pubmed: 16563663
Pharmacol Rev. 2016 Apr;68(2):242-63
pubmed: 26772794
Neural Plast. 2017;2017:9724371
pubmed: 28706741
Postgrad Med. 2017 Nov;129(8):902-906
pubmed: 28936887
J Neuropsychiatry Clin Neurosci. 1991 Winter;3(1):78-80
pubmed: 7580179
Neuroscientist. 2005 Feb;11(1):75-88
pubmed: 15632280
EXCLI J. 2019 Nov 05;18:1019-1036
pubmed: 31762726
J Pain. 2018 May;19(5):529-541
pubmed: 29355609
J Neurosci Nurs. 1997 Jun;29(3):179-86
pubmed: 9220365
J Gen Intern Med. 2002 Mar;17(3):173-9
pubmed: 11929502
Psychosom Med. 1997 Nov-Dec;59(6):572-7
pubmed: 9407574
J Gen Intern Med. 2014 Mar;29(3):491-9
pubmed: 24165926
Neurobiol Learn Mem. 2002 Nov;78(3):625-36
pubmed: 12559840
Nurse Res. 2016 Jul;23(6):20-5
pubmed: 27424963
Psychol Bull. 1995 Mar;117(2):285-305
pubmed: 7724692
Malawi Med J. 2012 Sep;24(3):69-71
pubmed: 23638278
J Pain. 2013 Nov;14(11):1255-69
pubmed: 24035349
Exp Anim. 2014;63(3):277-87
pubmed: 25077757
Stat Methods Med Res. 2006 Dec;15(6):525-45
pubmed: 17260922
Pain. 2007 Nov;132(1-2):206-10
pubmed: 17764843
Arch Intern Med. 2006 Oct 23;166(19):2087-93
pubmed: 17060538
J Anxiety Disord. 2002;16(2):149-64
pubmed: 12194541
Psychoneuroendocrinology. 2002 Jan-Feb;27(1-2):273-83
pubmed: 11750783
Nature. 1977 Apr 21;266(5604):730-2
pubmed: 559941
J Pharmacol Pharmacother. 2012 Oct;3(4):348
pubmed: 23326113
Bull Exp Biol Med. 2002 Feb;133(2):130-2
pubmed: 12428280
Adv Biomed Res. 2016 Nov 28;5:178
pubmed: 28028518
Nature. 2014 Jun 19;510(7505):340
pubmed: 24943947
Pain. 1996 Dec;68(2-3):343-7
pubmed: 9121823
Pain. 2000 Aug;87(2):113-9
pubmed: 10924804
Science. 2000 Jun 9;288(5472):1769-72
pubmed: 10846154
Neuropsychopharmacology. 2014 Nov;39(12):2777-87
pubmed: 24889368
Neuropharmacology. 2014 Jan;76 Pt B:269-75
pubmed: 23810828
J Neurochem. 2009 Jul;110(2):595-602
pubmed: 19457081
J Neurotrauma. 2012 May 20;29(8):1650-62
pubmed: 22214368
Neuron. 2004 Sep 30;44(1):75-91
pubmed: 15450161
Nature. 2002 Aug 1;418(6897):530-4
pubmed: 12152079
Methods Find Exp Clin Pharmacol. 1983 Nov;5(9):601-6
pubmed: 6668969
J Pain Symptom Manage. 2010 Aug;40(2):279-89
pubmed: 20579834
Eur J Pharmacol. 2011 Mar 5;654(2):166-72
pubmed: 21147096
Pharmacol Rep. 2006 Sep-Oct;58(5):746-52
pubmed: 17085867
Behav Pharmacol. 2019 Aug;30(5):435-445
pubmed: 30694818
Biol Psychiatry. 2011 Oct 15;70(8):763-9
pubmed: 21820648
Interdiscip Toxicol. 2013 Sep;6(3):126-35
pubmed: 24678249
ILAR J. 1999 Jun;40(3):119-128
pubmed: 11406690
Brain Res Bull. 2019 Jan;144:122-131
pubmed: 30503221
Am J Psychiatry. 2001 Aug;158(8):1181-3
pubmed: 11481146
Physiol Behav. 2018 Feb 1;184:143-149
pubmed: 29174820

Auteurs

Hamid Ahmadian-Moghadam (H)

Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.

Ardeshir Akbarabadi (A)

Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.

Heidar Toolee (H)

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Mitra Sadat Sadat-Shirazi (MS)

Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.

Solmaz Khalifeh (S)

Cognitive and Neuroscience Research Center, Amir Al-Momenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Saba Niknamfar (S)

Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Reza Zarrindast (MR)

Iranian National Center for Addiction Studies AND Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Classifications MeSH