Druggability profile of stilbene-derived PPAR agonists: determination of physicochemical properties and PAMPA study.
Journal
MedChemComm
ISSN: 2040-2511
Titre abrégé: Medchemcomm
Pays: England
ID NLM: 101531525
Informations de publication
Date de publication:
01 Nov 2019
01 Nov 2019
Historique:
received:
20
05
2019
accepted:
12
08
2019
entrez:
25
3
2020
pubmed:
25
3
2020
medline:
25
3
2020
Statut:
epublish
Résumé
PPAR agonists represent a new therapeutic opportunity for the prevention and treatment of neurodegenerative disorders, but their pharmacological success depends on favourable pharmacokinetic properties and capability to cross the BBB. In this study, we assayed some PPAR agonists previously synthesized by us for their physicochemical properties, with particular references to lipophilicity, solubility and permeability profiles, using the PAMPA. Although tested compounds showed high lipophilicity and low aqueous solubility, the results revealed a good overall druggability profile, encouraging further studies in the field of neurodegenerative diseases.
Identifiants
pubmed: 32206235
doi: 10.1039/c9md00286c
pii: c9md00286c
pmc: PMC7069374
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1892-1899Informations de copyright
This journal is © The Royal Society of Chemistry 2019.
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