Metal complexes as a promising source for new antibiotics.
Journal
Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951
Informations de publication
Date de publication:
14 Mar 2020
14 Mar 2020
Historique:
received:
20
12
2019
accepted:
10
02
2020
entrez:
25
3
2020
pubmed:
25
3
2020
medline:
25
3
2020
Statut:
epublish
Résumé
There is a dire need for new antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of known antibiotics, new classes of antibiotics are urgently required. Metal complexes are currently in clinical development for the treatment of cancer, malaria and neurodegenerative diseases. However, only little attention has been paid to their application as potential antimicrobial compounds. We report the evaluation of 906 metal-containing compounds that have been screened by the Community for Open Antimicrobial Drug Discovery (CO-ADD) for antimicrobial activity. Metal-bearing compounds display a significantly higher hit-rate (9.9%) when compared to the purely organic molecules (0.87%) in the CO-ADD database. Out of 906 compounds, 88 show activity against at least one of the tested strains, including fungi, while not displaying any cytotoxicity against mammalian cell lines or haemolytic properties. Herein, we highlight the structures of the 30 compounds with activity against Gram-positive and/or Gram-negative bacteria containing Mn, Co, Zn, Ru, Ag, Eu, Ir and Pt, with activities down to the nanomolar range against methicillin resistant
Identifiants
pubmed: 32206266
doi: 10.1039/c9sc06460e
pii: c9sc06460e
pmc: PMC7069370
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2627-2639Subventions
Organisme : Medical Research Council
ID : G0400848
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N002679/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P007503/1
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : T32 GM008500
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
This journal is © The Royal Society of Chemistry 2020.
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