Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride.
5-Aminolaevulinic acid hydrochloride
meningioma
photodynamic detection
protoporphyrin IX
Journal
JFMS open reports
ISSN: 2055-1169
Titre abrégé: JFMS Open Rep
Pays: England
ID NLM: 101672978
Informations de publication
Date de publication:
Historique:
entrez:
25
3
2020
pubmed:
25
3
2020
medline:
25
3
2020
Statut:
epublish
Résumé
The present study describes the case of a feline meningioma that was detected using 5-aminolaevulinic acid hydrochloride (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence at surgery. An extra-axial mass in the temporoparietal region was observed by MRI. Following craniectomy and durotomy, photodynamic detection (PDD) was performed for detection of the tumour. Intratumour PpIX was detected using fluorescence spectrum evaluation and high-performance liquid chromatography. PDD revealed bright fluorescence of PpIX induced by 5-ALA, facilitating fluorescence-guided resection of the tumour tissue. Postoperative examination demonstrated an intratumour PpIX protein concentration of 16.8 nmol/g, and based on histopathological findings we diagnosed the mass as meningioma. PDD using 5-ALA has been used to identify the surgical margins during resection of primary human brain tumours. Recently, we have reported post-mortem PDD using 5-ALA for a canine glioblastoma. To our knowledge, this technique has not been previously used for the detection and resection of feline brain tumours. Our findings suggest that PDD using 5-ALA is useful for intraoperative fluorescence-guided resection of malignant meningioma in cats.
Identifiants
pubmed: 32206327
doi: 10.1177/2055116920907429
pii: 10.1177_2055116920907429
pmc: PMC7074522
doi:
Types de publication
Case Reports
Langues
eng
Pagination
2055116920907429Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Conflict of interest: Narumi Kunisue, Kiwamu Takahashi, Masahiro Ishizuka, and Tohru Tanaka are employees of SBI Pharmaceuticals.
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