Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): results of a placebo-controlled, cross-over clinical trial.
Anxiety
Depression
Oxaloacetate
Premenstrual syndrome
Suicidal ideation
Journal
Obstetrics & gynecology science
ISSN: 2287-8572
Titre abrégé: Obstet Gynecol Sci
Pays: Korea (South)
ID NLM: 101602614
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
09
05
2019
revised:
07
09
2019
accepted:
04
11
2019
entrez:
25
3
2020
pubmed:
25
3
2020
medline:
25
3
2020
Statut:
ppublish
Résumé
Premenstrual syndrome (PMS) affects millions of women. While over-the-counter products have helped with the physical symptoms of PMS, emotional symptoms have been less well supported. The objective of this trial was to measure the effect of an oxaloacetate/vitamin C combination on the major emotional symptoms of PMS, including depression, anxiety, perceived stress, aggression, and suicidal ideation. Forty-eight women experiencing PMS completed a baseline survey comprising the Beck's Depression Inventory, Cohen Perceived Stress Scale, Generalized Anxiety Disorder Test, and Buss-Perry Aggression Questionnaire. After baseline measurements, participants were randomly assigned to take either 2 capsules of 100 mg oxaloacetate/150 mg ascorbic acid, or 2 capsules of rice flour (placebo) for their entire menstrual cycle. At menstruation, the women completed the 4 surveys again. The women then switched capsules in a cross-over design and continued the study for an additional menstrual cycle. The final assessment was repeated at menstruation. Statistical analysis of the 4 surveys was performed to examine efficacy. Oxaloacetate/vitamin C supplementation during PMS significantly improved depression, perceived stress, anxiety, aggression, and suicidal ideation. The mean improvement in depression was 54.1%, 35.8% for perceived stress, 51.43% for generalized anxiety, and 17.8% for aggression. Suicidal ideation was reduced by 47.9%. All results were highly significant. A combination of oxaloacetate and vitamin C supplementation helped to alleviate depression, anxiety, perceived stress, aggression, and suicidal ideation symptoms associated with PMS. ClinicalTrials.gov Identifier: NCT03509714.
Identifiants
pubmed: 32206660
doi: 10.5468/ogs.2020.63.2.195
pmc: PMC7073356
doi:
Banques de données
ClinicalTrials.gov
['NCT03509714']
Types de publication
Journal Article
Langues
eng
Pagination
195-204Informations de copyright
Copyright © 2020 Korean Society of Obstetrics and Gynecology.
Déclaration de conflit d'intérêts
Conflict of interest: No potential conflict of interest relevant to this article was reported.
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