Identification of a common conserved neutralizing linear B-cell epitope in the VP3 protein of waterfowl parvoviruses.
Goose parvovirus
Muscovy duck parvovirus
VP3 protein
epitope
monoclonal antibody
novel goose parvovirus-related virus
Journal
Avian pathology : journal of the W.V.P.A
ISSN: 1465-3338
Titre abrégé: Avian Pathol
Pays: England
ID NLM: 8210638
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
pubmed:
27
3
2020
medline:
16
3
2021
entrez:
27
3
2020
Statut:
ppublish
Résumé
Waterfowl parvoviruses (WPVs) including goose parvovirus (GPV), novel GPV-related virus (NGPV) and Muscovy duck parvovirus (MDPV) cause significant economic losses and epizootic threat to the waterfowl industries, and little is known about the B-cell epitopes of WPVs. In this study, a monoclonal antibody (mAb) 5B5 against the VP3 protein of NGPV was used to identify the possible epitope in the three kinds of WPVs. The mAb 5B5 had neutralizing activities to the three viruses, and reacted with the conserved linear B-cell epitopes of
Identifiants
pubmed: 32208867
doi: 10.1080/03079457.2020.1746743
doi:
Substances chimiques
Antibodies, Monoclonal
0
Epitopes, B-Lymphocyte
0
Viral Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM