Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide.
Phthalimide
anti-inflammatory
anti-tumor
antimicrobial
medicinal chemistry
thalidomide
Journal
Current organic synthesis
ISSN: 1570-1794
Titre abrégé: Curr Org Synth
Pays: United Arab Emirates
ID NLM: 101208457
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
08
2019
revised:
20
02
2020
accepted:
21
02
2020
pubmed:
27
3
2020
medline:
20
7
2021
entrez:
27
3
2020
Statut:
ppublish
Résumé
Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant. The most well-known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide: this compound initially presented important sedative effects, but it is now known that thalidomide has effectiveness against a wide variety of diseases, including inflammation and cancer. This review approaches some of the recent and efficient chemical synthesis pathways to obtain phthalimide analogues and also presents a summary of the main biological activities of these derivatives found in the literature. Therefore, this review describes the chemical and therapeutic aspects of phthalimide derivatives.
Identifiants
pubmed: 32209046
pii: COS-EPUB-105482
doi: 10.2174/1570179417666200325124712
doi:
Substances chimiques
Phthalimides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
252-270Informations de copyright
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