Ultrasound assisted rapid synthesis of mefenamic acid based indole derivatives under ligand free Cu-catalysis: Their pharmacological evaluation.
Binding Sites
Blood-Brain Barrier
/ drug effects
Catalysis
Copper
/ chemistry
Cyclic Nucleotide Phosphodiesterases, Type 4
/ chemistry
Cyclization
Half-Life
Humans
Indoles
/ chemistry
Mefenamic Acid
/ chemistry
Molecular Docking Simulation
Phosphodiesterase 4 Inhibitors
/ chemistry
Sonication
Structure-Activity Relationship
Tumor Necrosis Factor-alpha
/ antagonists & inhibitors
Cu
Indole
Mefenamic acid
PDE4
Ultrasound
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
15 05 2020
15 05 2020
Historique:
received:
25
01
2020
revised:
13
03
2020
accepted:
13
03
2020
pubmed:
27
3
2020
medline:
1
5
2021
entrez:
27
3
2020
Statut:
ppublish
Résumé
An improved and rapid synthesis of mefenamic acid based indole derivatives has been achieved via the ligand free Cu-catalyzed coupling-cyclization method under ultrasound irradiation. This simple, straightforward and inexpensive one-pot method involved the reaction of a terminal alkyne derived from mefenamic acid with 2-iodosulfanilides in the presence of CuI and K
Identifiants
pubmed: 32209292
pii: S0960-894X(20)30201-8
doi: 10.1016/j.bmcl.2020.127112
pii:
doi:
Substances chimiques
Indoles
0
Phosphodiesterase 4 Inhibitors
0
Tumor Necrosis Factor-alpha
0
Mefenamic Acid
367589PJ2C
Copper
789U1901C5
Cyclic Nucleotide Phosphodiesterases, Type 4
EC 3.1.4.17
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
127112Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.