Guidance on development and operation of Young Persons' Advisory Groups.


Journal

Archives of disease in childhood
ISSN: 1468-2044
Titre abrégé: Arch Dis Child
Pays: England
ID NLM: 0372434

Informations de publication

Date de publication:
09 2020
Historique:
received: 17 11 2019
revised: 17 02 2020
accepted: 23 02 2020
pubmed: 27 3 2020
medline: 21 10 2020
entrez: 27 3 2020
Statut: ppublish

Résumé

Engaging patients and the public as collaborators in research is increasingly recognised as important as such partnerships can help improve research relevance and acceptability. Young Persons' Advisory Groups (YPAGs) provide a forum for clinical researchers and triallists to engage with children and young people on issues relevant to the design, conduct and translation of paediatric clinical trials. Until fairly recently, there was very little information available to guide the successful development and operation of YPAGs. To develop an evidence-based tool to guide clinical researchers and triallists in the establishment and operation of a YPAG. An online needs assessment survey was conducted using SurveyMonkey with 60 known paediatric drug researchers to identify knowledge gaps around YPAG engagement, development and operation. Semistructured interviews with founders and coordinators of five well-established existing YPAGs and a review of the literature were performed to identify best-practice processes for starting up and operating YPAG. The majority of 12 survey respondents (20%) from 12 different centres indicated that while they felt YPAGs could benefit their research, guidance on how to develop and operate a YPAG was needed. Most preferred a web-based guidance tool. Ten core steps in starting up and operating a YPAG were identified and developed into an online YPAG guidance tool, now freely accessible for use by paediatric clinical researchers worldwide. Plans to evaluate the impact are in place. This novel tool, developed with an internationally based group of public involvement leads working across paediatric clinical research areas, provides harmonised guidance for researchers seeking to develop and operate YPAGs to help improve the quality and impact of paediatric clinical research studies.

Sections du résumé

BACKGROUND
Engaging patients and the public as collaborators in research is increasingly recognised as important as such partnerships can help improve research relevance and acceptability. Young Persons' Advisory Groups (YPAGs) provide a forum for clinical researchers and triallists to engage with children and young people on issues relevant to the design, conduct and translation of paediatric clinical trials. Until fairly recently, there was very little information available to guide the successful development and operation of YPAGs.
OBJECTIVE
To develop an evidence-based tool to guide clinical researchers and triallists in the establishment and operation of a YPAG.
METHODS
An online needs assessment survey was conducted using SurveyMonkey with 60 known paediatric drug researchers to identify knowledge gaps around YPAG engagement, development and operation. Semistructured interviews with founders and coordinators of five well-established existing YPAGs and a review of the literature were performed to identify best-practice processes for starting up and operating YPAG.
RESULTS
The majority of 12 survey respondents (20%) from 12 different centres indicated that while they felt YPAGs could benefit their research, guidance on how to develop and operate a YPAG was needed. Most preferred a web-based guidance tool. Ten core steps in starting up and operating a YPAG were identified and developed into an online YPAG guidance tool, now freely accessible for use by paediatric clinical researchers worldwide. Plans to evaluate the impact are in place.
CONCLUSIONS
This novel tool, developed with an internationally based group of public involvement leads working across paediatric clinical research areas, provides harmonised guidance for researchers seeking to develop and operate YPAGs to help improve the quality and impact of paediatric clinical research studies.

Identifiants

pubmed: 32209556
pii: archdischild-2019-318517
doi: 10.1136/archdischild-2019-318517
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

875-880

Informations de copyright

© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Winnie Chan (W)

Child Health Evaluative Sciences, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Pravheen Thurairajah (P)

Child Health Evaluative Sciences, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Nancy Butcher (N)

Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, Ontario, Canada.

Cor Oosterwijk (C)

Dutch Genetic Alliance, VSOP, Soest, The Netherlands.

Kim Wever (K)

Dutch Genetic Alliance, VSOP, Soest, The Netherlands.

Irmgard Eichler (I)

Department of Paediatrics, European Medicines Agency and Enpr-EMA, London, UK.

Charles Thompson (C)

International Children's Advisory Network (iCAN), Hartford, Connecticut, USA.

Anne Junker (A)

Department of Pediatrics, The University of British Columbia, Vancouver, British Columbia, Canada.

Martin Offringa (M)

Child Health Evaluative Sciences, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Jennifer Preston (J)

Women's and Children's Health, University of Liverpool School of Life Sciences, Liverpool, UK Jennifer.Preston@liverpool.ac.uk.

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Classifications MeSH