The Microbial Community of Tetrodotoxin-Bearing and Non-Tetrodotoxin-Bearing Ribbon Worms (Nemertea) from the Sea of Japan.
Nemertea
TTX
TTX-bearing animals
TTX-producing bacteria
microbiota
tetrodotoxin
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
23 Mar 2020
23 Mar 2020
Historique:
received:
13
02
2020
revised:
20
03
2020
accepted:
20
03
2020
entrez:
27
3
2020
pubmed:
27
3
2020
medline:
29
12
2020
Statut:
epublish
Résumé
A potent marine toxin, tetrodotoxin (TTX), found in a great variety of marine and some terrestrial species, leaves intriguing questions about its origin and distribution in marine ecosystems. TTX-producing bacteria were found in the cultivable microflora of many TTX-bearing hosts, thereby providing strong support for the hypothesis that the toxin is of bacterial origin in these species. However, metagenomic studies of TTX-bearing animals addressing the whole microbial composition and estimating the contribution of TTX-producing bacteria to the overall toxicity of the host were not conducted. The present study is the first to characterize and compare the 16S rRNA gene data obtained from four TTX-bearing and four non-TTX-bearing species of marine ribbon worms. The statistical analysis showed that different nemertean species harbor distinct bacterial communities, while members of the same species mostly share more similar microbiomes. The bacterial species historically associated with TTX production were found in all studied samples but predominated in TTX-bearing nemertean species. This suggests that deeper knowledge of the microbiome of TTX-bearing animals is a key to understanding the origin of TTX in marine ecosystems.
Identifiants
pubmed: 32210160
pii: md18030177
doi: 10.3390/md18030177
pmc: PMC7143766
pii:
doi:
Substances chimiques
DNA, Bacterial
0
RNA, Ribosomal, 16S
0
Tetrodotoxin
4368-28-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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