Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain.
Animals
Brain
/ metabolism
Cognition
Disease Models, Animal
Fatty Acid Binding Protein 3
/ antagonists & inhibitors
Fluorescent Antibody Technique
Humans
Immunohistochemistry
Mice
Mice, Knockout
Neurons
/ metabolism
Phosphorylation
Synucleinopathies
/ etiology
Tyrosine 3-Monooxygenase
/ metabolism
alpha-Synuclein
/ administration & dosage
fatty acid binding protein 3
α-synuclein
α-synuclein propagation
α-synucleinopathy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Mar 2020
23 Mar 2020
Historique:
received:
30
01
2020
revised:
07
03
2020
accepted:
17
03
2020
entrez:
27
3
2020
pubmed:
27
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Oligomerization and/or aggregation of α-synuclein (α-Syn) triggers α-synucleinopathies such as Parkinson's disease and dementia with Lewy bodies. It is known that α-Syn can spread in the brain like prions; however, the mechanism remains unclear. We demonstrated that fatty acid binding protein 3 (FABP3) promotes propagation of α-Syn in mouse brain. Animals were injected with mouse or human α-Syn pre-formed fibrils (PFF) into the bilateral substantia nigra pars compacta (SNpc). Two weeks after injection of mouse α-Syn PFF, wild-type (WT) mice exhibited motor and cognitive deficits, whereas FABP3 knock-out (
Identifiants
pubmed: 32210174
pii: ijms21062230
doi: 10.3390/ijms21062230
pmc: PMC7139546
pii:
doi:
Substances chimiques
Fatty Acid Binding Protein 3
0
alpha-Synuclein
0
Tyrosine 3-Monooxygenase
EC 1.14.16.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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