Platelet Mitochondrial Respiration, Endogenous Coenzyme Q
chronic kidney disease
coenzyme Q10
mitochondria
oxidative stress
platelets
respiration
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
23 Mar 2020
23 Mar 2020
Historique:
received:
30
01
2020
revised:
13
03
2020
accepted:
19
03
2020
entrez:
27
3
2020
pubmed:
27
3
2020
medline:
27
3
2020
Statut:
epublish
Résumé
Chronic kidney disease (CKD) is characterized by a progressive loss of renal function and a decrease of glomerular filtration rate. Reduced mitochondrial function, coenzyme Q Twenty-seven CKD patients were enrolled in this trial, 17 patients had arterial hypertension (AH) and 10 patients had arterial hypertension and diabetes mellitus (AH and DM). The control group consisted of 12 volunteers. A high-resolution respirometry (HRR) method was used for the analysis of mitochondrial bioenergetics in platelets, and an HPLC method with UV detection was used for CoQ Platelets mitochondrial respiration showed slight, not significant differences between the groups of CKD patients and control subjects. The oxygen consumption by intact platelets positively correlated with the concentration of CoQ A decreased concentration of CoQ
Identifiants
pubmed: 32210203
pii: diagnostics10030176
doi: 10.3390/diagnostics10030176
pmc: PMC7151406
pii:
doi:
Types de publication
Journal Article
Langues
eng
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