Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 03 2020
24 03 2020
Historique:
received:
09
04
2019
accepted:
08
01
2020
entrez:
27
3
2020
pubmed:
27
3
2020
medline:
16
7
2020
Statut:
epublish
Résumé
In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of allergic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus that produces short chain fatty acids and endotoxins, each of which may promote the development of fetal immune tolerance. In this study, we use a prebirth cohort (n = 1064 mothers) to conduct a nested case-cohort study comparing 58 mothers of babies with clinically proven food IgE mediated food allergy with 258 randomly selected mothers. Analysis of the V4 region of the 16S rRNA gene in fecal samples shows maternal carriage of Prevotella copri during pregnancy strongly predicts the absence of food allergy in the offspring. This association was confirmed using targeted qPCR and was independent of infant carriage of P. copri. Larger household size, which is a well-established protective factor for allergic disease, strongly predicts maternal carriage of P. copri.
Identifiants
pubmed: 32210229
doi: 10.1038/s41467-020-14552-1
pii: 10.1038/s41467-020-14552-1
pmc: PMC7093478
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1452Investigateurs
Sanjay Vashee
(S)
Manolito Torralba
(M)
Andres Gomez
(A)
Terrence Dwyer
(T)
David Burgner
(D)
Michael Forrester
(M)
Christos Symeonides
(C)
Esther Bandala Sanchez
(E)
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