Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 03 2020
24 03 2020
Historique:
received:
14
11
2018
accepted:
16
12
2019
entrez:
27
3
2020
pubmed:
27
3
2020
medline:
28
7
2020
Statut:
epublish
Résumé
The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes.
Identifiants
pubmed: 32210231
doi: 10.1038/s41467-020-14451-5
pii: 10.1038/s41467-020-14451-5
pmc: PMC7093467
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1536Subventions
Organisme : Cancer Research UK
ID : C5047/A7357
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C16913/A6135
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5047/A10692
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5047/A3354
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201200008C
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148537
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 10118
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202802/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12015/2
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C1287/A16563
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U01 CA188392
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00006/2
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C1287/A10118
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102215/2/13/2
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201200008I
Pays : United States
Investigateurs
Rosalind A Eeles
(RA)
Brian E Henderson
(BE)
Christopher A Haiman
(CA)
Zsofia Kote-Jarai
(Z)
Fredrick R Schumacher
(FR)
Ali Amin Al Olama
(AAA)
Sara Benlloch
(S)
Kenneth Muir
(K)
Sonja I Berndt
(SI)
David V Conti
(DV)
Fredrik Wiklund
(F)
Stephen Chanock
(S)
Susan Gapstur
(S)
Victoria L Stevens
(VL)
Catherine M Tangen
(CM)
Jyotsna Batra
(J)
Judith Clements
(J)
Henrik Gronberg
(H)
Nora Pashayan
(N)
Johanna Schleutker
(J)
Demetrius Albanes
(D)
Alicja Wolk
(A)
Catharine West
(C)
Lorelei Mucci
(L)
Géraldine Cancel-Tassin
(G)
Stella Koutros
(S)
Karina Dalsgaard Sorensen
(KD)
Eli Marie Grindedal
(EM)
David E Neal
(DE)
Freddie C Hamdy
(FC)
Jenny L Donovan
(JL)
Ruth C Travis
(RC)
Robert J Hamilton
(RJ)
Sue Ann Ingles
(SA)
Barry S Rosenstein
(BS)
Yong-Jie Lu
(YJ)
Graham G Giles
(GG)
Adam S Kibel
(AS)
Ana Vega
(A)
Manolis Kogevinas
(M)
Kathryn L Penney
(KL)
Jong Y Park
(JY)
Janet L Stanford
(JL)
Cezary Cybulski
(C)
Børge G Nordestgaard
(BG)
Hermann Brenner
(H)
Christiane Maier
(C)
Jeri Kim
(J)
Esther M John
(EM)
Manuel R Teixeira
(MR)
Susan L Neuhausen
(SL)
Kim De Ruyck
(K)
Azad Razack
(A)
Lisa F Newcomb
(LF)
Davor Lessel
(D)
Radka Kaneva
(R)
Nawaid Usmani
(N)
Frank Claessens
(F)
Paul A Townsend
(PA)
Manuela Gago-Dominguez
(M)
Monique J Roobol
(MJ)
Florence Menegaux
(F)
Kay-Tee Khaw
(KT)
Lisa Cannon-Albright
(L)
Hardev Pandha
(H)
Stephen N Thibodeau
(SN)
Michelle Agee
(M)
Babak Alipanahi
(B)
Adam Auton
(A)
Robert K Bell
(RK)
Katarzyna Bryc
(K)
Sarah L Elson
(SL)
Pierre Fontanillas
(P)
Nicholas A Furlotte
(NA)
David A Hinds
(DA)
Karen E Huber
(KE)
Aaron Kleinman
(A)
Nadia K Litterman
(NK)
Matthew H McIntyre
(MH)
Joanna L Mountain
(JL)
Elizabeth S Noblin
(ES)
Carrie A M Northover
(CAM)
Steven J Pitts
(SJ)
J Fah Sathirapongsasuti
(JF)
Olga V Sazonova
(OV)
Janie F Shelton
(JF)
Suyash Shringarpure
(S)
Chao Tian
(C)
Joyce Y Tung
(JY)
Vladimir Vacic
(V)
Catherine H Wilson
(CH)
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