Influence of estrous stages on electrocardiography, clinical pathology and ovarian weight of experimental beagle dogs: a retrospective analysis.
beagle dogs
clinical pathology
electrocardiography
estrous cycle
ovarian weight
Journal
Interdisciplinary toxicology
ISSN: 1337-6853
Titre abrégé: Interdiscip Toxicol
Pays: Slovakia
ID NLM: 101528175
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
18
05
2017
accepted:
09
01
2019
entrez:
27
3
2020
pubmed:
27
3
2020
medline:
27
3
2020
Statut:
ppublish
Résumé
Estrous cycle is a repetitive phenomenon occurring during the reproductive life of a female dog. The duration of the canine estrous cycle is considerably longer than one in the most of the other animals and is broadly grouped into follicular phase (proestrus and estrus), luteal phase (diestrus) and non-seasonal anestrus. Dogs in the same stage of cycle can be inadvertently assigned to same group during routine safety and metabolic studies leading to possible erroneous interpretation of test-item related effects. This retrospective analysis was conducted by analyzing data of 86 female beagle dogs from control/placebo treated groups to correlate any possible effect of estrous stages with electrocardiography, clinical pathology and ovarian weight. Different estrous cycle stages of beagles were confirmed histologically by evaluating ovary, uterus, vagina and mammary glands. The incidence of beagles in diestrus was the highest, followed by anestrus, proestrus and estrus. No significant effect was noticed on heart rate, P-A, P-D, RR, QRS and QT intervals across different stages of estrous cycle. However, significantly higher PQ (PR) interval in dogs in proestrus stage was observed compared to dogs in anestrus and estrus. Marginally higher WBCs, neutrophils, lymphocytes, RBCs, hemoglobin, AST and lower hematocrit, lipid profile (total cholesterol, HDL, LDL, triglycerides), ALP level was evident in estrous period. Relative ovary weight was significantly higher in dogs in diestrus stage. Considering these results, one may need to exercise caution while interpreting experimental data from female beagle dogs.
Identifiants
pubmed: 32210704
doi: 10.2478/intox-2019-0018
pii: ITX-12-149
pmc: PMC7085299
doi:
Types de publication
Journal Article
Langues
eng
Pagination
149-156Informations de copyright
Copyright © 2019 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc.
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