Structure-Function of the High Affinity Substrate Binding Site (S1) of Human Norepinephrine Transporter.
docking guided mutagenesis
molecular modeling
monoamine transporter
noradrenaline uptake
structural determinants
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
10
2019
accepted:
14
02
2020
entrez:
27
3
2020
pubmed:
27
3
2020
medline:
27
3
2020
Statut:
epublish
Résumé
The human norepinephrine transporter (hNET) is a member of the neurotransmitter/sodium symporter family, which also includes the neuronal monoamine transporters for serotonin (SERT) and dopamine (DAT). Its involvement in chronic pain and many neurological disorders underlies its pharmaceutical importance. Using the X-ray crystal structures of the human serotonin transporter (hSERT) (PDB 5I6X) and
Identifiants
pubmed: 32210813
doi: 10.3389/fphar.2020.00217
pmc: PMC7066499
doi:
Types de publication
Journal Article
Langues
eng
Pagination
217Informations de copyright
Copyright © 2020 Jha, Ragnarsson and Lewis.
Références
AAPS J. 2005 Oct 27;7(3):E728-38
pubmed: 16353949
Bioinformatics. 2007 Nov 1;23(21):2947-8
pubmed: 17846036
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12137-42
pubmed: 21730142
Nature. 2005 Sep 8;437(7056):215-23
pubmed: 16041361
Lancet. 1999 Dec 18-25;354(9196):2132-3
pubmed: 10609822
Nat Struct Mol Biol. 2009 Jun;16(6):652-7
pubmed: 19430461
PLoS One. 2011;6(9):e25647
pubmed: 21980516
J Biol Chem. 2006 Jan 27;281(4):2012-23
pubmed: 16272152
Nature. 2013 Nov 7;503(7474):85-90
pubmed: 24037379
Nat Rev Neurosci. 2003 Jan;4(1):13-25
pubmed: 12511858
ACS Chem Neurosci. 2013 Feb 20;4(2):295-309
pubmed: 23421681
Methods Enzymol. 2003;374:461-91
pubmed: 14696385
J Neurosci. 2003 Jun 1;23(11):4470-8
pubmed: 12805287
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W39-43
pubmed: 15980496
J Biol Chem. 2010 Apr 9;285(15):11270-80
pubmed: 20159976
Drugs Future. 2004 Dec;29(12):1235-1244
pubmed: 16871320
Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):12-21
pubmed: 20057044
Nature. 2015 May 21;521(7552):322-7
pubmed: 25970245
Mol Pharmacol. 2010 Dec;78(6):1026-35
pubmed: 20829432
Nat Neurosci. 2008 Jul;11(7):780-9
pubmed: 18568020
Pflugers Arch. 2004 Feb;447(5):519-31
pubmed: 12719981
Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7782-5
pubmed: 1502198
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15810-5
pubmed: 21885739
Pharmacol Rev. 1999 Sep;51(3):439-64
pubmed: 10471414
J Neurochem. 2008 Nov;107(4):928-40
pubmed: 18786172
Am J Psychiatry. 1988 Aug;145(8):1015-7
pubmed: 2839998
Nature. 2016 Apr 21;532(7599):334-9
pubmed: 27049939
J Biol Chem. 1997 Nov 7;272(45):28321-7
pubmed: 9353288
Cell Res. 1998 Dec;8(4):311-5
pubmed: 9934539
Pain. 1995 Oct;63(1):11-20
pubmed: 8577481
J Neurosci. 1997 Nov 1;17(21):8451-8
pubmed: 9334417
Proteins. 2008 Apr;71(1):261-77
pubmed: 17932912
J Biol Chem. 1998 Oct 23;273(43):28098-106
pubmed: 9774428
Mol Pharmacol. 2012 Nov;82(5):898-909
pubmed: 22874414
J Biol Chem. 2012 Dec 21;287(52):43694-707
pubmed: 23086945
Mol Pharmacol. 1999 Aug;56(2):434-47
pubmed: 10419565
ACS Chem Neurosci. 2016 Nov 16;7(11):1607-1613
pubmed: 27596073
J Biol Chem. 2010 Jan 15;285(3):2051-63
pubmed: 19892699