NLGP Attenuates Murine Melanoma and Carcinoma Metastasis by Modulating Cytotoxic CD8

B16F10 CD8+ T cells LLC NLGP antigen presentation dendritic cells metastasis metastatic colonization

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2020
Historique:
received: 12 09 2019
accepted: 05 02 2020
entrez: 27 3 2020
pubmed: 27 3 2020
medline: 27 3 2020
Statut: epublish

Résumé

Neem leaf glycoprotein (NLGP), a natural immunomodulator, attenuates murine carcinoma and melanoma metastasis, independent of primary tumor growth and alterations in basic cellular properties (cell proliferation, cytokine secretion, etc.). Colonization event of invasion-metastasis cascade was primarily inhibited by NLGP, with no effect on metastasis-related invasion, migration, and extravasation. High infiltration of interferon γ (IFN-γ)-secreting cytotoxic CD8

Identifiants

pubmed: 32211313
doi: 10.3389/fonc.2020.00201
pmc: PMC7076076
doi:

Types de publication

Journal Article

Langues

eng

Pagination

201

Informations de copyright

Copyright © 2020 Bhuniya, Guha, Ganguly, Saha, Dasgupta, Nandi, Das, Ghosh, Ghosh, Haque, Banerjee, Bose and Baral.

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Auteurs

Avishek Bhuniya (A)

Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India.

Ipsita Guha (I)

Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India.

Nilanjan Ganguly (N)

Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India.

Akata Saha (A)

Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India.

Shayani Dasgupta (S)

Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India.

Partha Nandi (P)

Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India.

Arnab Das (A)

RNA Biology and Research Laboratory, Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.

Sarbari Ghosh (S)

Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India.

Tithi Ghosh (T)

Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India.

Enamul Haque (E)

Department of Zoology, Barasat Government College, Barasat, India.

Saptak Banerjee (S)

Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India.

Anamika Bose (A)

Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India.

Rathindranath Baral (R)

Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India.

Classifications MeSH