Gait Initiation in Parkinson's Disease: Impact of Dopamine Depletion and Initial Stance Condition.
Parkinson’s disease
anthropometric measurements
basal ganglia
base of support
dopamine
gait initiation
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
10
2019
accepted:
11
02
2020
entrez:
27
3
2020
pubmed:
27
3
2020
medline:
27
3
2020
Statut:
epublish
Résumé
Postural instability, in particular at gait initiation (GI), and resulting falls are a major determinant of poor quality of life in subjects with Parkinson's disease (PD). Still, the contribution of the basal ganglia and dopamine on the feedforward postural control associated with this motor task is poorly known. In addition, the influence of anthropometric measures (AM) and initial stance condition on GI has never been consistently assessed. The biomechanical resultants of anticipatory postural adjustments contributing to GI [imbalance (IMB), unloading (UNL), and stepping phase) were studied in 26 unmedicated subjects with idiopathic PD and in 27 healthy subjects. A subset of 13 patients was analyzed under standardized medication conditions and the striatal dopaminergic innervation was studied in 22 patients using FP-CIT and SPECT. People with PD showed a significant reduction in center of pressure (CoP) displacement and velocity during the IMB phase, reduced first step length and velocity, and decreased velocity and acceleration of the center of mass (CoM) at toe off of the stance foot. All these measurements correlated with the dopaminergic innervation of the putamen and substantially improved with levodopa. These results were not influenced by anthropometric parameters or by the initial stance condition. In contrast, most of the measurements of the UNL phase were influenced by the foot placement and did not correlate with putaminal dopaminergic innervation. Our results suggest a significant role of dopamine and the putamen particularly in the elaboration of the IMB phase of anticipatory postural adjustments and in the execution of the first step. The basal ganglia circuitry may contribute to defining the optimal referent body configuration for a proper initiation of gait and possibly gait adaptation to the environment.
Identifiants
pubmed: 32211390
doi: 10.3389/fbioe.2020.00137
pmc: PMC7068722
doi:
Types de publication
Journal Article
Langues
eng
Pagination
137Informations de copyright
Copyright © 2020 Palmisano, Brandt, Vissani, Pozzi, Canessa, Brumberg, Marotta, Volkmann, Mazzoni, Pezzoli, Frigo and Isaias.
Références
Clin Biomech (Bristol, Avon). 2019 Mar;63:140-146
pubmed: 30889433
Mov Disord. 2015 Sep;30(10):1361-70
pubmed: 26095928
Brain. 2019 Jul 1;142(7):2037-2050
pubmed: 31505548
Mov Disord. 1997 Mar;12(2):206-15
pubmed: 9087979
Gait Posture. 1998 Aug 1;8(1):8-14
pubmed: 10200394
J Neurophysiol. 2015 Jul;114(1):301-8
pubmed: 25925329
J Biomech. 1996 May;29(5):619-25
pubmed: 8707788
J Neurosci. 2015 Feb 11;35(6):2703-16
pubmed: 25673860
Neurosci Lett. 2006 Oct 2;406(1-2):128-32
pubmed: 16901637
Parkinsonism Relat Disord. 2009 Jan;15(1):6-11
pubmed: 18424221
Neuroscience. 2009 Dec 1;164(2):877-85
pubmed: 19665521
Eur J Nucl Med Mol Imaging. 2013 Apr;40(4):565-73
pubmed: 23232506
Physiology (Bethesda). 2016 Mar;31(2):95-107
pubmed: 26889015
PLoS One. 2016 Jun 03;11(6):e0156420
pubmed: 27258183
J Neurophysiol. 2011 Aug;106(2):915-24
pubmed: 21525376
J Neurosci. 2012 Nov 21;32(47):16704-15
pubmed: 23175824
Exp Brain Res. 2006 Jul;172(4):519-32
pubmed: 16555105
Arch Phys Med Rehabil. 2005 Nov;86(11):2172-6
pubmed: 16271566
PLoS One. 2014 Apr 17;9(4):e92736
pubmed: 24743294
J R Soc Interface. 2017 Mar;14(128):
pubmed: 28275124
Phys Ther. 2002 Jun;82(6):566-77
pubmed: 12036398
J Neurosci. 2011 Oct 12;31(41):14458-62
pubmed: 21994362
Cereb Cortex. 2006 Oct;16(10):1508-21
pubmed: 16373457
Eur J Neurosci. 2018 Sep;48(6):2362-2373
pubmed: 30117212
J Physiol. 1991 Jun;437:635-53
pubmed: 1890653
J Neurosci. 2007 Jul 4;27(27):7105-16
pubmed: 17611263
Gait Posture. 2012 Mar;35(3):452-7
pubmed: 22154114
PLoS One. 2018 Jun 6;13(6):e0198691
pubmed: 29874298
Mov Disord. 2006 Aug;21(8):1144-7
pubmed: 16671078
Front Aging Neurosci. 2018 Feb 15;10:36
pubmed: 29497374
Prog Neurobiol. 1992;38(1):35-56
pubmed: 1736324
J Neurophysiol. 2007 Jun;97(6):4368-79
pubmed: 17460098