Histomorphological evaluations on the frontal cortex extrapyramidal cell layer following administration of N-Acetyl cysteine in aluminum induced neurodegeneration rat model.
Acetylcysteine
/ therapeutic use
Aluminum
Aluminum Chloride
/ toxicity
Alzheimer Disease
/ chemically induced
Animals
Antioxidants
/ therapeutic use
Astrocytes
/ metabolism
Extrapyramidal Tracts
/ pathology
Glial Fibrillary Acidic Protein
/ metabolism
Gliosis
/ drug therapy
Male
Necrosis
Neurodegenerative Diseases
/ chemically induced
Neurons
/ pathology
Neuroprotective Agents
/ therapeutic use
Oxidative Stress
/ drug effects
Prefrontal Cortex
/ pathology
Rats
Rats, Wistar
Aluminum
Astrocytes and oxidative stress
Chromatolysis
N-acetyl cysteine (NAC)
Journal
Metabolic brain disease
ISSN: 1573-7365
Titre abrégé: Metab Brain Dis
Pays: United States
ID NLM: 8610370
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
08
10
2019
accepted:
24
02
2020
pubmed:
27
3
2020
medline:
10
7
2021
entrez:
27
3
2020
Statut:
ppublish
Résumé
Aluminum is a potent neurotoxin used in animal models of neurodegenerative diseases like Alzheimer's disease (AD), in which oxidative stress mediates tissue pathogenesis in vivo. N-acetyl cysteine (NAC) is a glutathione precursor with reported antioxidant and neuroprotective potentials. Recent therapy for combating AD is known to provide only symptomatic relief thus necessitating the discovery of new drugs and their mechanism of action. This study was aimed to demonstrate the in vivo neuroprotective effect of NAC against aluminum (Al
Identifiants
pubmed: 32212044
doi: 10.1007/s11011-020-00556-9
pii: 10.1007/s11011-020-00556-9
pmc: PMC7220982
doi:
Substances chimiques
Antioxidants
0
Glial Fibrillary Acidic Protein
0
Neuroprotective Agents
0
Aluminum Chloride
3CYT62D3GA
Aluminum
CPD4NFA903
Acetylcysteine
WYQ7N0BPYC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
829-839Références
Abbasali KM, Zhila T, Farshad N (2005) Developmental toxicity of aluminum from high doses of AlCl
Adair JC, Knoefel JE, Morgan N (2001) Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease. Neurology 57:1515–1517
pubmed: 11673605
Ahmad RM, Justin TA, Manivasagam T, Dhivya BM, Essa MM, Guillemin GJ (2018) Neuroprotective role of Asiatic acid in aluminum chloride-induced rat model of Alzheimer's disease. Front Biosci (Schol Ed) 1(10):262–275
Akinrinade ID, Memudu AE, Ogundele OM, Ajetunmobi OI (2015a) Interplay of glia activation and oxidative stress formation in fluoride and aluminum exposure. Pathophysiology 22:39–48
Akinrinade ID, Memudu AE, Ogundele OM (2015b) Fluoride and aluminum disturb neuronal morphology, transport functions, cholinesterase, lysosomal and cell cycle activities. Pathophysiology 22:105–115
Ali AA, Ahmed HI, Elfotuh KA (2016) Modeling stages mimic Alzheimer’s disease induced by different doses of aluminum in rats: focus on progression of the disease in response to time. Journal of Alzheimer’s Parkinsonism & Dementia 1(1):1–11
Alternative Medicine Review (AMR) (2003) AMR Monographs, N-acetylcysteine, vol Volume 1. Thorne Research, Inc., Dover
Asher BF, Guilford FT (2016) Oxidative stress and low glutathione3 in common ear, nose, and throat conditions: a systematic review. Altern Ther Health Med 22(5):44–50
pubmed: 27622960
Auti ST, Kulkarni YA (2019) Neuroprotective effect of cardamom oil against aluminum induced neurotoxicity in rats. Front Neurol. https://doi.org/10.3389/fneur.2019.00399
Bachurin SO, Bovina EV, Ustyugov AA (2017) Drugs in clinical trials for Alzheimer’s disease: the major trends. Med Res Rev 37:1186–1225. https://doi.org/10.1002/med.21434
doi: 10.1002/med.21434
pubmed: 28084618
Bancroft JD, Gamble M (2008) Theory and practice of histological techniques, 6th edn. Churchill Livingstone, London
Batlle M, Ferri L, Andrade C, Ortega FJ, Vidal-Taboada JM, Pugliese M et al (2015) Astroglia-microglia cross talk during neurodegeneration in the rat hippocampus. Biomed Res Int 102419
Becaria A, Bondy SC, Campbell A (2003) Aluminum and copper interact in the promotion of oxidative but not inflammatory events: implications for Alzheimer’s disease. J Alzheimers Dis 5:31–38
pubmed: 12590164
Berk M, Dean OM, Cotton SM, Jeavons S, Tanious M, Kohlmann K, Hewitt K, Moss K, Allwang C, Schapkaitz I, Robbins J, Cobb H, Ng F, Dodd S, Bush AI, Malhi GS (2014) The efficacy of adjunctive Nacetylcysteine in major depressive disorder: a double-blind, randomized, placebo-controlled trial. J Clin Psychiatry 75(6):628–636
pubmed: 25004186
Bhattacharya B, Mangilal T, Nagakishore R (2014) Alzheimer’s disease-pathophysiology, diagnosis and modern approach to treatment. World J Pharm Pharm Sci 3(10):1452–1460
Buraimoh AA, Ojo SA, Hambolu JO (2011) Effects of Oral Administration of Aluminum Chloride on the histology of the Hippocampus of Wistar rats. Curr Res J Biol Sci 3(5):509–515 ISSN: 2041-0778
Chino NJ, Sorathias SD, Jhala DD (2005) Fluoride and aluminum induced toxicity in mice testis with giant cells and its reversal by vitamin C. Fluoride 38(2):109–114
Chiroma SM, Mohd Moklas MA, Mat Taib CN, Baharuldin MTH, Amon Z (2018) D-galactose and aluminium chloride induced rat model with cognitive impairments. Biomed Pharmacother L 103:1602–1608. https://doi.org/10.1016/j.biopha.2018.04.152
doi: 10.1016/j.biopha.2018.04.152
Ciroma S, Mohamad AM, Che NMT, Mohammad THB, Zulkhairi A (2018) D- galactos and aluminum chloride induced rat model with cognitive impairments. Biomed Pharmacother 103:1602–1608
Dean OM, Van den B, Berk M, Copolov M, David L, Mavros C, Bush AI (2011) N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: relevance to schizophrenia and bipolar disorder. Neurosci Lett 499:149–153
pubmed: 21621586
Deepmala SJ, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R (2015) Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review. Neurosci Biobehav Rev 55:294–321. https://doi.org/10.1016/j.neubiorev.2015.04.015
doi: 10.1016/j.neubiorev.2015.04.015
pubmed: 25957927
Du L, Empey PE, Chao H, Kochanek PM, Bavir H, Clark RS (2016) Probenecid and N-ACETYL cysteine prevent loss of intracellular glutathione and Inibits cell death after Maechanical stress injury in vitro. J.Neurotrauma. 33(20):1913–1917
pubmed: 26830358
pmcid: 5079409
Durieux AM, Fernandes C, Murphy D, Labouesse MA, Giovanoli S, Meyer U, Li Q, So P, McAlonan G (2015) Targeting glia with N-Acetylcysteine modulates brain glutamate and behaviors relevant to neurodevelopmental disorders in C57BL/6J mice. Front Behav Neurosci 14(9):343. https://doi.org/10.3389/fnbeh.2015.00343
doi: 10.3389/fnbeh.2015.00343
Farrell SE (2018). What is the mechanism of action of N-acetylcysteine (NAC) in the treatment of acetaminophen toxicity/ poisoning? Drug and diseases. Medscape
Gao X, Lampraki E-M, Al-Khalidi S, Qureshi MA, Desai R, Wilson JB (2017) N-acetylcysteine (NAC) ameliorates Epstein-Barr virus latent membrane protein 1 induced chronic inflammation. PLoS One 12(12):e0189167. https://doi.org/10.1371/journal.pone.0189167
doi: 10.1371/journal.pone.0189167
pubmed: 29228057
pmcid: 5724866
Giancarlo A, Alessandra A, Giovanna B, Giulio V, Marina C, Luisa B, Francesco S (2018) N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res 52(7):751–762. https://doi.org/10.1080/10715762.2018.1468564
doi: 10.1080/10715762.2018.1468564
Gil-Martínez A, Cuenca L, Sánchez C, Estrada C, Fernández-Villalba E, Herrero MT (2018) Effect of NAC treatment and physical activity on neuroinflammation in subchronic parkinsonism; is physical activity essential? J Neuroinflammation 15:328. https://doi.org/10.1186/s12974-018-1357-4
doi: 10.1186/s12974-018-1357-4
pubmed: 30477535
pmcid: 6260767
Gosselin RE, Smith RP, Hodge HC (2004) Clinical toxicology of commercial products, 5th edn. Williams and Wilkins, Baltimore
Gu F, Chauhan V, Chauhan A (2015) Glutathione redox imbalance in brain disorders. Curr Opin Clin Nutr Metab Care 18(1):89–95
pubmed: 25405315
Hanaa HA, Hanaa M, Serage WG (2015) Black berry juice attenuates neurological disorders and oxidative stress associated with concurrent exposure of aluminum and fluoride in male rats. Egyptian Journal of Basic and Applied Sciences 2(4):281–288
Homma T, Fujii J (2015) Application of glutathione as anti-oxidative and anti-aging drugs. Curr Drug Metab 16(7):560–571
pubmed: 26467067
Huang Y, Herman MM, Liu J, Katsetos CD, Wills MR, Savory J (1997) Neurofibrillary lesions in experimental aluminum-induced encephalopathy and Alzheimer's disease share immunoreactivity for amyloid precursor protein, a beta, alpha 1-antichymotrypsin and ubiquitin-protein conjugates. Brain Res 771(2):213–220
pubmed: 9401741
Jellinger KA (2013) The relevance of metals in the pathophysiology of neurodegeneration: pathological considerations. Int Rev Neurobiol 170:1–47
Johnston RE, Hawkins HC, Weikel JH (1983) The toxicity of N-acetylcysteine in laboratory animals. Semin Oncol 10:17–24
pubmed: 6682250
KaddourTaïr OK, Oussama A, Nouria H, Iméne B, Abdelkader A (2016) Aluminum-induced acute neurotoxicity in rats: treatment with aqueous extract of Arthrophytum (Hammada scoparia). Journal of Acute Disease 5(6):470–482
Kasolo JN, Na-maganda A, Bbosa GS, Muwonge H, Lukande R, Nfambi J, Kimuli I, Okullo I (2019) Reversal effects of N-acetyl Cyste-ine on Moringa oleifera leaves-induced sub- acute hepatotoxicity in Wistar albino rats. Neuroscience & Medicine 10:385–397. https://doi.org/10.4236/nm.2019.104028
doi: 10.4236/nm.2019.104028
Keyes RC, Cittolin-Satons GF, Kim JE, Won ST, Brenan-Minnella AM, Katz M, Glass GA, Swanson RA (2016) Neuronal glutathione content and antioxidant capacity can be normalized in situ by N-acetylCysteine concentration attained in human cerebrospinal fluid. Neuotherapeutics 13(1):217–225
Lide DR (2008) CRC handbook of chemistry and physics, 81st edn. CRC press, LLc, Broca Raton Fl.P. 4-39
Mayeux R (2010) Early Alzheimer’s disease. N Engl J Med 362:2194–2201. https://doi.org/10.1056/NEJMcp0910236
doi: 10.1056/NEJMcp0910236
pubmed: 20558370
McGeer PL, McGeer EG (2008) Glial reactions in Parkinson’s disease. Mov Disord 23(4):474–483
pubmed: 18044695
McLachlan DRC, Bergeron C, Smith JE, Boomer D, Rifat SL (1996) Risk for neuropathologically confirmed Alzheimer's disease and residual aluminum in municipal drinking water employing weighted residential histories. Neurology. 46(2):401–405
pubmed: 8614502
Miller RL, James-Kracke M, Sun GY, Sun AY (2009) Oxidative and inflammatory pathways in Parkinson’s disease. Neurochem Res 34(1):55–65
pubmed: 18363100
Mokhtari V, Afsharian P, Shahhoseini M, Kalantar SM, Moini A (2017) A review on various uses of N-acetyl cysteine. Cell J 19(1):11–17. https://doi.org/10.22074/cellj.2016.4872
doi: 10.22074/cellj.2016.4872
pubmed: 28367412
National Research Council (2011) Guide for the care and use of laboratory animals, 6th edn. National Academic Press, Washington, D.C.
Nehru B, Bhalla P, Garg A (2007) Further evidence of centrophenoxine mediated protection in aluminium exposed rats by biochemical and light microscopy analysis. Food Chem Toxicol 45(12):2499–2505
pubmed: 17688990
Ortiz MS, Forti KM, Suarez-Martinez EB, Munoz LG, Husian K, Muniz WH (2016) Effect of antioxidant N-acetyl cysteine against Paraquat –induced oxidative stress in vital tissue in mice. Int J SciBasic ApplRes 26(1):26–26
Ovais M, Zia N, Ahmad I, Khalil AT, Raza A, Ayaz M, Sadiq A, Ullah F, Shinwari ZK (2018) Phyto-therapeutic and nanomedicinal approach to cure Alzheimer disease: present status and future opportunities. Front Aging Neurosci 10:284. https://doi.org/10.3389/fnagi.2018.00284
doi: 10.3389/fnagi.2018.00284
pubmed: 30405389
pmcid: 6205985
Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates, 6th edn. Academic Press, New York
Praveenkumar SE, Bairy KL, Nayak V, Reddy SK, Kiran A, Ballal A (2019) Amelioration of Aluminium Chloride (AlCl
Prema A, Thenmozhi AJ, Manivasagam T, Essa MM, Akbar MD, Akbar M (2017) Fenugreek seed powder nullified Aluminium chloride induced memory loss, biochemical changes, burden, and apoptosis via regulation signaling pathway. PLoS One 11(11):e0165955
Ramachandran S, Sanjay AS, Dhanaraju MD (2013) Antiamnesic effect of Piracetam potentiated with Emblica officinalis and Curcuma longa in aluminium induced neurotoxicity of Alzheimer’s disease. Int J Adv Res 1(7):185–196
Raza H, John A, Shafarin J (2014) NAC attenuates LPS-induced toxicity in aspirin-sensitized mouse macrophages via suppression of oxidative stress and mitochondrial dysfunction. PLoS One 9(7). https://doi.org/10.1371/journal.pone.0103379
Reddy SK, Sudheer A, Arunamma M, Sree PL, Jyothirmayi E (2017) Protective effect of Picrorhizakurroa on Alzheimer’s disease induced by aluminum chloride in rats. Int J Basic Clin Pharmacol 6:602–607
Samuni YS, Goldstein O, Dean M, Berk M (2013) The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta 1830:4117–4129
pubmed: 23618697
Shahripour RB, Harrigan MR, Alexandrov AV (2014) N-acetyl cysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities. Brain and Behavior 4(2):108–122. https://doi.org/10.1002/brb3.208
doi: 10.1002/brb3.208
Šimkevičienė V, Straukas J, Uleckienė S (2002) N-Acetil-L-cysteine and 2-Amino-2-Thiazoline N-acetyl-L-Cysteinate as a possible Cancer Chemopreventive agents in murine models. Biologia Futura 53:293–298. https://doi.org/10.1556/ABiol.53.2002.3.5
doi: 10.1556/ABiol.53.2002.3.5
Tchantchou F, Graves M, Rogers M, Ortiz D, Shea TB (2005) N-acteyl cysteine alleviates oxidative damage to central nervous system of ApoE-deficient mice following folate and vitamin E-deficiency. J Alzheimers Dis 7:135–138
pubmed: 15851851
Virk SA, Eslik GD (2015) Aluminum levels in the brain, serum and cerebrospinal fluid are higher in Alzheimer’s disease cases than in controls: a series of metaanalysis. J Alzheimers Dis 47(3):629–638
pubmed: 26401698
Walton JR (2013) Aluminum involvement in the progression of Alzheimer’s disease. J Alzheimers Dis 35(1):7–43
pubmed: 23380995
Wang Q, Hou Y, Yi D, Wang L, Ding B, Chen X (2013) Protective effects of N-acetyl cysteine on acetic acid-induced colitis in a porcine model. BMC Gastroenterol 13:133–133
pubmed: 24001404
pmcid: 3844587
Wang Q, Liu Y, Zhou J (2015) Neuroinflammation in Parkinson’s disease and its potential as therapeutic target. Transl Neurodegener 4(1):19
pubmed: 26464797
pmcid: 4603346
WHO (1997) Aluminum. Geneva, World Health Organization, International Programme on Chemical Safety (Environmental Health Criteria 194)
Yen-Koo HC (1992) The effect of aluminum on conditioned avoidance response (CAR) in mice. Toxicol Ind Health 8:1–7
pubmed: 1542881
Yokel RA (2005) The toxicology of aluminum in brain: review. Neurotoxicology 21(5):813–828
Yokel RA, McNamara PJ (2001) Aluminum toxicokinetics: an updated mini-review. Pharmacol Toxicol 88:159–167
pubmed: 11322172