Suppression of Ca
EGR4
K channels
STIM1
Th1 differentiation
cancer immunity
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
06 05 2020
06 05 2020
Historique:
received:
19
07
2019
revised:
24
02
2020
accepted:
27
02
2020
pubmed:
27
3
2020
medline:
28
4
2021
entrez:
27
3
2020
Statut:
ppublish
Résumé
While the zinc finger transcription factors EGR1, EGR2, and EGR3 are recognized as critical for T-cell function, the role of EGR4 remains unstudied. Here, we show that EGR4 is rapidly upregulated upon TCR engagement, serving as a critical "brake" on T-cell activation. Hence, TCR engagement of EGR4
Identifiants
pubmed: 32212315
doi: 10.15252/embr.201948904
pmc: PMC7202224
doi:
Substances chimiques
Early Growth Response Transcription Factors
0
Egr4 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e48904Subventions
Organisme : NIAID NIH HHS
ID : R01 AI143256
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS040748
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127351
Pays : United States
Organisme : NINDS NIH HHS
ID : K02 NS046468
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI068907
Pays : United States
Organisme : NIH HHS
ID : K26 OD010945
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117907
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI143256
Pays : United States
Organisme : NCRR NIH HHS
ID : K26 RR026099
Pays : United States
Organisme : W J Avery Foundation
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL154757
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA193711
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM107179
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006927
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095894
Pays : United States
Informations de copyright
© 2020 The Authors.
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