Resting state networks activity in euthymic bipolar disorder.
Adult
Bipolar Disorder
/ physiopathology
Brain
/ physiopathology
Brain Mapping
Case-Control Studies
Cerebellum
/ physiopathology
Cyclothymic Disorder
/ physiopathology
Female
Gyrus Cinguli
/ physiopathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Parietal Lobe
/ physiopathology
Quality of Life
Young Adult
bipolar disorder
default mode network
network analysis
resting-state fMRI
Journal
Bipolar disorders
ISSN: 1399-5618
Titre abrégé: Bipolar Disord
Pays: Denmark
ID NLM: 100883596
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
pubmed:
27
3
2020
medline:
15
12
2020
entrez:
27
3
2020
Statut:
ppublish
Résumé
Bipolar disorder (BD) is a psychiatric condition causing shifts in mood, energy and activity levels severely altering the quality of life of the patients even in the euthymic phase. Although widely accepted, the neurobiological bases of the disorder in the euthymic phase remain elusive. This study aims at characterizing resting state functional activity of the BD euthymic phase in order to better understand the pathogenesis of the disease and build future neurobiological models. Fifteen euthymic BD patients (10 females; mean age 40.2; standard deviation 13.5; range 20-61) and 27 healthy controls (HC) (21 females; mean age 37; standard deviation 10.6; range 22-60) underwent a 3T functional MRI scan at rest. Resting state activity was extracted through independent component analysis (ICA) run with automatic dimensionality estimation. ICA identified 22 resting state networks (RSNs). Within-network analysis revealed decreased connectivity in the visual, temporal, motor and cerebellar RSNs of BD patients vs HC. Between-network analysis showed increased connectivity between motor area and the default mode network (DMN) partially overlapping with the fronto-parietal network (FPN) in BD patients. Within-network analysis confirmed existing evidence of altered cerebellar, temporal, motor and visual networks in BD. Increased connectivity between the DMN and the motor area network suggests the presence of alterations of the fronto-parietal regions, precuneus and cingulate cortex in the euthymic condition. These findings indicate that specific connectivity alterations might persist even in the euthymic state suggesting the importance of examining both within and between-network connectivity to achieve a global understanding of the BD euthymic condition.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
593-601Subventions
Organisme : Ministero della Salute
ID : GR-2010-2319022 (MB)
Pays : International
Organisme : Ministero della Salute
ID : GR-2016-02361283 (CP)
Pays : International
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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