Prevalence of coexisting autoimmune thyroidal diseases in coeliac disease is decreasing.
Adolescent
Adult
Aged
Aged, 80 and over
Arthritis, Rheumatoid
/ epidemiology
Celiac Disease
/ epidemiology
Comorbidity
/ trends
Diabetes Mellitus, Type 1
/ epidemiology
Female
Humans
Hypothyroidism
/ epidemiology
Inflammatory Bowel Diseases
/ epidemiology
Ireland
/ epidemiology
Male
Middle Aged
Prevalence
Psoriasis
/ epidemiology
Retrospective Studies
Thyroiditis, Autoimmune
/ epidemiology
Young Adult
Autoimmune thyroid disease
coeliac disease
environmental factors
epidemiology
genotypes
gluten
immune-mediated conditions
type 1 diabetes
Journal
United European gastroenterology journal
ISSN: 2050-6414
Titre abrégé: United European Gastroenterol J
Pays: England
ID NLM: 101606807
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
entrez:
28
3
2020
pubmed:
28
3
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
Coeliac disease (CD) is associated with an increased risk of other immune-mediated conditions. Medical record data were collected retrospectively from 749 CD patients in Ireland. Prevalence of autoimmune diseases was compared with previously published results from general populations. Patients were divided into four groups based on the year of diagnosis to analyse changes in the prevalence of autoimmune thyroidal disease over time. Median age at the time of CD diagnosis was 56 years (range 18-91 years). A total of 233 (31.1%) patients had a coexistent immune-mediated condition (IMC). Autoimmune thyroidal diseases were seen in 149 (19.9%) patients, hypothyroidism in 110 (14.7%), type 1 diabetes in 27 (3.6%), psoriasis in 20 (2.7%), inflammatory bowel disease in 14 (1.9%) and rheumatoid arthritis in 12 (1.6%). All conditions were more common in CD patients than in the general population. Type 1 diabetes was diagnosed mainly before CD, whereas there was no such trend in other conditions. Autoimmune thyroidal diseases became less common in female CD patients over time. Prevalence of autoimmune diseases is increased in adult CD patients compared with the general population. However, concomitant autoimmune thyroidal diseases became less common over time in women.
Sections du résumé
BACKGROUND
Coeliac disease (CD) is associated with an increased risk of other immune-mediated conditions.
METHODS
Medical record data were collected retrospectively from 749 CD patients in Ireland. Prevalence of autoimmune diseases was compared with previously published results from general populations. Patients were divided into four groups based on the year of diagnosis to analyse changes in the prevalence of autoimmune thyroidal disease over time.
RESULTS
Median age at the time of CD diagnosis was 56 years (range 18-91 years). A total of 233 (31.1%) patients had a coexistent immune-mediated condition (IMC). Autoimmune thyroidal diseases were seen in 149 (19.9%) patients, hypothyroidism in 110 (14.7%), type 1 diabetes in 27 (3.6%), psoriasis in 20 (2.7%), inflammatory bowel disease in 14 (1.9%) and rheumatoid arthritis in 12 (1.6%). All conditions were more common in CD patients than in the general population. Type 1 diabetes was diagnosed mainly before CD, whereas there was no such trend in other conditions. Autoimmune thyroidal diseases became less common in female CD patients over time.
CONCLUSIONS
Prevalence of autoimmune diseases is increased in adult CD patients compared with the general population. However, concomitant autoimmune thyroidal diseases became less common over time in women.
Identifiants
pubmed: 32213077
doi: 10.1177/2050640619899225
pmc: PMC7079276
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
148-156Références
Gut. 1994 Jun;35(6):776-8
pubmed: 8020804
Curr Diab Rep. 2013 Dec;13(6):795-804
pubmed: 24072479
Dig Liver Dis. 2016 Jul;48(7):740-4
pubmed: 27133207
Science. 2017 Apr 7;356(6333):44-50
pubmed: 28386004
Clin Gastroenterol Hepatol. 2018 Jun;16(6):823-836.e2
pubmed: 29551598
World J Gastroenterol. 2007 Mar 21;13(11):1715-22
pubmed: 17461476
Clin Gastroenterol Hepatol. 2015 Jul;13(7):1271-1277.e2
pubmed: 25645875
J Autoimmun. 2009 Nov-Dec;33(3-4):197-207
pubmed: 19819109
Inflamm Bowel Dis. 2005 Jun;11(6):528-32
pubmed: 15905699
Cell. 2015 Jan 29;160(3):447-60
pubmed: 25619688
J Autoimmun. 2008 Sep;31(2):160-5
pubmed: 18692362
Indian J Dermatol. 2017 Jan-Feb;62(1):41-46
pubmed: 28216724
JAMA. 2019 Aug 13;322(6):514-523
pubmed: 31408136
Nutrients. 2018 May 12;10(5):
pubmed: 29757210
J Pediatr. 2009 Jul;155(1):51-5, 55.e1
pubmed: 19324373
Int J Clin Exp Med. 2015 Dec 15;8(12):22529-42
pubmed: 26885239
Scand J Gastroenterol. 2012 Jan;47(1):43-8
pubmed: 22126672
Diabetes. 2011 Mar;60(3):1045-9
pubmed: 21307077
BMJ. 2019 Feb 13;364:l231
pubmed: 30760441
Clin Gastroenterol Hepatol. 2019 Jun;17(7):1311-1322.e7
pubmed: 30389589
Thyroid. 2008 Nov;18(11):1171-8
pubmed: 19014325
J Pediatr. 2015 Nov;167(5):1109-15.e1
pubmed: 26316370
Clin Gastroenterol Hepatol. 2008 Jul;6(7):753-8
pubmed: 18255352
Arthritis Rheum. 2010 Jun;62(6):1576-82
pubmed: 20191579
Endocrine. 2012 Oct;42(2):252-65
pubmed: 22644837
Am J Gastroenterol. 2013 May;108(5):818-24
pubmed: 23511460
JAMA Pediatr. 2019 Aug 12;:
pubmed: 31403683
Thyroid. 2016 Jul;26(7):880-90
pubmed: 27256300
Curr Opin Gastroenterol. 2006 Nov;22(6):674-9
pubmed: 17053448
BMC Gastroenterol. 2014 Nov 18;14:194
pubmed: 25404189
Dig Liver Dis. 2008 Oct;40(10):809-13
pubmed: 18467196
J Intern Med. 2011 Jun;269(6):591-603
pubmed: 21401738
Diabetes Care. 2015 Oct;38 Suppl 2:S37-44
pubmed: 26405070
Diabetol Metab Syndr. 2016 Jul 29;8:51
pubmed: 27478507