Chronic Ethanol Feeding in Mice Decreases Expression of Genes for Major Structural Bone Proteins in a Nox4-Independent Manner.

Animals Bone Density / drug effects Bone and Bones / drug effects Ethanol / administration & dosage Female Gene Expression / drug effects Genotype Male Mice Mice, Knockout NADPH Oxidase 4 / genetics NADPH Oxidases / genetics Osteoblasts / drug effects Oxidation-Reduction / drug effects Oxidative Stress / drug effects Reactive Oxygen Species / metabolism

Journal

The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362

Informations de publication

Date de publication:
06 2020
Historique:
received: 03 12 2019
accepted: 23 03 2020
pubmed: 28 3 2020
medline: 12 9 2020
entrez: 28 3 2020
Statut: ppublish

Résumé

Bone loss in response to alcohol intake has previously been hypothesized to be mediated by excessive production of reactive oxygen species via NADPH oxidase (Nox) enzymes. Nox4 is one of several Nox enzymes expressed in bone. We investigated the role of Nox4 in the chondro-osteoblastic lineage of the long bones in mice during normal chow feeding and during chronic ethanol feeding for 90 days. We generated mice with a genotype (

Identifiants

DOI: 10.1124/jpet.119.264374 PMID: 32213546 PMC: PMC7228502
pubmed: 32213546
pii: jpet.119.264374
doi: 10.1124/jpet.119.264374
pmc: PMC7228502
doi:

Substances chimiques

Reactive Oxygen Species 0
Ethanol 3K9958V90M
NADPH Oxidase 4 EC 1.6.3.-
NADPH Oxidases EC 1.6.3.-
Nox4 protein, mouse EC 1.6.3.-

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

337-346

Subventions

Organisme : NIAAA NIH HHS
ID : T32 AA007577
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA018282
Pays : United States
Organisme : NIAAA NIH HHS
ID : T35 AA021097
Pays : United States
Organisme : NIAAA NIH HHS
ID : F32 AA026480
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA018282
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM121189
Pays : United States

Informations de copyright

Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics.

Déclaration de conflit d'intérêts

The authors declare that they have no conflicts of interest.

Références

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Auteurs

Kim B Pedersen (KB)

Department of Pharmacology & Experimental Therapeutics, Louisiana State Health Sciences Center (LSUHSC), New Orleans, Louisiana (K.B.P., A.C.R., A.E.W., J.W., A.D., M.J.R.); Comparative Biomedical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, Baton Rouge, Louisiana (M.L.O.); and Institute of Physiology I, Goethe-University, Frankfurt, Germany (K.S.).

Michelle L Osborn (ML)

Department of Pharmacology & Experimental Therapeutics, Louisiana State Health Sciences Center (LSUHSC), New Orleans, Louisiana (K.B.P., A.C.R., A.E.W., J.W., A.D., M.J.R.); Comparative Biomedical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, Baton Rouge, Louisiana (M.L.O.); and Institute of Physiology I, Goethe-University, Frankfurt, Germany (K.S.).

Alex C Robertson (AC)

Department of Pharmacology & Experimental Therapeutics, Louisiana State Health Sciences Center (LSUHSC), New Orleans, Louisiana (K.B.P., A.C.R., A.E.W., J.W., A.D., M.J.R.); Comparative Biomedical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, Baton Rouge, Louisiana (M.L.O.); and Institute of Physiology I, Goethe-University, Frankfurt, Germany (K.S.).

Ashlee E Williams (AE)

Department of Pharmacology & Experimental Therapeutics, Louisiana State Health Sciences Center (LSUHSC), New Orleans, Louisiana (K.B.P., A.C.R., A.E.W., J.W., A.D., M.J.R.); Comparative Biomedical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, Baton Rouge, Louisiana (M.L.O.); and Institute of Physiology I, Goethe-University, Frankfurt, Germany (K.S.).

James Watt (J)

Department of Pharmacology & Experimental Therapeutics, Louisiana State Health Sciences Center (LSUHSC), New Orleans, Louisiana (K.B.P., A.C.R., A.E.W., J.W., A.D., M.J.R.); Comparative Biomedical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, Baton Rouge, Louisiana (M.L.O.); and Institute of Physiology I, Goethe-University, Frankfurt, Germany (K.S.).

Alexandra Denys (A)

Department of Pharmacology & Experimental Therapeutics, Louisiana State Health Sciences Center (LSUHSC), New Orleans, Louisiana (K.B.P., A.C.R., A.E.W., J.W., A.D., M.J.R.); Comparative Biomedical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, Baton Rouge, Louisiana (M.L.O.); and Institute of Physiology I, Goethe-University, Frankfurt, Germany (K.S.).

Katrin Schröder (K)

Department of Pharmacology & Experimental Therapeutics, Louisiana State Health Sciences Center (LSUHSC), New Orleans, Louisiana (K.B.P., A.C.R., A.E.W., J.W., A.D., M.J.R.); Comparative Biomedical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, Baton Rouge, Louisiana (M.L.O.); and Institute of Physiology I, Goethe-University, Frankfurt, Germany (K.S.).

Martin J Ronis (MJ)

Department of Pharmacology & Experimental Therapeutics, Louisiana State Health Sciences Center (LSUHSC), New Orleans, Louisiana (K.B.P., A.C.R., A.E.W., J.W., A.D., M.J.R.); Comparative Biomedical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, Baton Rouge, Louisiana (M.L.O.); and Institute of Physiology I, Goethe-University, Frankfurt, Germany (K.S.) mronis@lsuhsc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Densité osseuse › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › NADPH oxidase › NADPH Oxidase 4 › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › NADPH oxidase › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Chronic Ethanol Feeding in Mice Decreases...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Chronic Ethanol Feeding in Mice Decreases...