Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial.
African American (AA)
abdominal aortic calcification (AAC)
chronic kidney disease (CKD)
dual-energy X-ray absorptiometry (DXA)
extended aortic calcification (AAC24)
parathyroid hormone
vascular calcification (VC)
vertebral fracture assessment (VFA)
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
24 Mar 2020
24 Mar 2020
Historique:
received:
28
02
2020
revised:
17
03
2020
accepted:
20
03
2020
entrez:
28
3
2020
pubmed:
28
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Abdominal aortic calcification (AAC) detected on lateral vertebral fracture assessment is associated with increased cardiovascular risk. Vitamin D deficiency and toxicity have been linked with vascular calcification. The objective of this study was to determine the effect of high-dose vitamin D on the progression of AAC. The Physical Performance, Osteoporosis and vitamin D in African American Women (PODA) is a randomized, clinical trial examining the effect of vitamin D. There were 14.7% subjects with AAC in the vitamin D group, compared to 12.1% in the placebo group at baseline. The prevalence of extended AAC at baseline was 6.4% in the vitamin D group and 3.5% in the placebo group. The extended calcification scores over time were not different between groups. There was no association between AAC and serum 25(OH)D. However, PTH was associated with an increase in AAC in the placebo group.
Identifiants
pubmed: 32213826
pii: nu12030861
doi: 10.3390/nu12030861
pmc: PMC7146156
pii:
doi:
Substances chimiques
Biomarkers
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : RO1-AG032440
Pays : United States
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