Perioperative symptomatic venous thromboembolism after immediate chemoprophylaxis in patients with pelvic and lower-extremity fractures.
Adult
Aged
Anticoagulants
/ administration & dosage
Bones of Lower Extremity
/ injuries
Chemoprevention
Dabigatran
/ administration & dosage
Enoxaparin
/ administration & dosage
Female
Fractures, Bone
/ complications
Humans
Male
Middle Aged
Multidetector Computed Tomography
Pelvic Bones
/ injuries
Pulmonary Embolism
/ diagnostic imaging
Risk Factors
Sex Factors
Venous Thromboembolism
/ diagnostic imaging
Venous Thrombosis
/ diagnostic imaging
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
25 03 2020
25 03 2020
Historique:
received:
16
10
2019
accepted:
12
03
2020
entrez:
28
3
2020
pubmed:
28
3
2020
medline:
17
12
2020
Statut:
epublish
Résumé
The purpose of this study was to investigate the incidence of symptomatic venous thromboembolism (VTE) after chemoprophylaxis in patients with pelvic and lower-extremity fractures, and to identify risk factors for VTEs in this subgroup of patients. To detect VTE, multi-detector computed tomography (CT) angiography was performed. Of 363 patients assessed, the incidence of symptomatic VTE was 12.4% (45 patients), and the incidence of symptomatic PE was 5.2% (19 patients). For the risk-factor analysis, a higher Charlson comorbidity index (p = 0.037), and a history of external fixator application (p = 0.007) were associated with increased VTE risk. Among patients who had VTE, male sex (p = 0.017), and above-the-knee fractures (p = 0.035) were associated with increased pulmonary embolism (PE) risk. In conclusions, the incidence of VTE in post-traumatic patients is not low after chemoprophylaxis. Risk factors for VTE and PE are different among patients with pelvic and lower-extremity fractures.
Identifiants
pubmed: 32214183
doi: 10.1038/s41598-020-62333-z
pii: 10.1038/s41598-020-62333-z
pmc: PMC7096457
doi:
Substances chimiques
Anticoagulants
0
Enoxaparin
0
Dabigatran
I0VM4M70GC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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