Eosinophilic pancreatitis: a rare or unexplored disease entity?
eosinophilic pancreatitis
eosinophils
hypereosinophilic syndrome
pancreatic neoplasia
pancreatitis
Journal
Przeglad gastroenterologiczny
ISSN: 1895-5770
Titre abrégé: Prz Gastroenterol
Pays: Poland
ID NLM: 101280380
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
02
2019
accepted:
09
03
2019
entrez:
28
3
2020
pubmed:
28
3
2020
medline:
28
3
2020
Statut:
ppublish
Résumé
Several case reports show accumulation of eosinophils in pancreatitis patients and term the disease as "eosinophilic pancreatitis (EP)". EP usually presents with a pancreatic tumour and abdominal pain in obstructive jaundice, which is generally not diagnosed until the patient undergoes pancreatic resection. Histologically, EP reveals distinct patterns like diffused, periductal, acinar, and septal inflammatory infiltrates with eosinophils, eosinophilic phlebitis, and localised extreme eosinophilic infiltrates related with pseudocyst formation. EP patients also have elevated serum IgE levels with high eosinophil counts in the pancreas as well as in other organs such as the gastrointestinal tract, which is termed as eosinophilic gastroenteritis. Due to the lack of knowledge based on just a few case reports, it is considered that eosinophilic infiltration is quite rare in the pancreas; therefore, the significance of eosinophils in pancreatitis is not yet established. This review assesses the current understanding of eosinophilic pancreatitis and the important role of eosinophils in promoting pancreatic fibrosis including malignancy.
Identifiants
pubmed: 32215125
doi: 10.5114/pg.2019.90631
pii: 38919
pmc: PMC7089860
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
34-38Informations de copyright
Copyright © 2020 Termedia.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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