Twenty-one year experience with intrauterine inseminations after controlled ovarian stimulation with gonadotropins: maternal age is the only prognostic factor for success.
Adult
Female
Fertilization in Vitro
Gonadotropins
/ therapeutic use
Humans
Infertility, Female
/ physiopathology
Insemination, Artificial
Live Birth
/ epidemiology
Male
Maternal Age
Ovarian Follicle
/ growth & development
Ovulation Induction
Pregnancy
Pregnancy Rate
Prognosis
Spermatozoa
/ growth & development
Infertility
Intrauterine Insemination
Maternal Age
Ovarian Reserve
Journal
Journal of assisted reproduction and genetics
ISSN: 1573-7330
Titre abrégé: J Assist Reprod Genet
Pays: Netherlands
ID NLM: 9206495
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
30
10
2019
accepted:
17
03
2020
pubmed:
28
3
2020
medline:
14
1
2021
entrez:
28
3
2020
Statut:
ppublish
Résumé
To report our experience on homologous intrauterine insemination (IUI) with gonadotropin controlled ovarian stimulation (COS) cycles and to examine different variables which could predict IUI success. This is a retrospective analysis of IUIs performed between January 1997 and December 2017. A total of 7359 COS IUI's procedures (2901 couples) were reviewed. Clinical pregnancy, live birth rate and age, body mass index (BMI), smoking habit, duration of infertility, sperm characteristics before and after treatment (total motile count, morphology, and vitality), day 3 FSH, total gonadotropin dose, and number of follicles were assessed by multivariate logistic regression analysis, and data were expressed as odds ratio (OR). The mean female age at the time of COS was 35.10 ± 3.93 years. The most common single infertility diagnoses were unexplained infertility (53.55%), mild male factor (19.69%), and anovulation (10.95%). The total progressive motile sperm count (TPMC) was > 1 × 10 Clinical pregnancy rate and live birth rates after COS-IUIs were significantly influenced by female age and FSH levels. Clinical trial registration number: NCT03836118.
Identifiants
pubmed: 32215826
doi: 10.1007/s10815-020-01752-3
pii: 10.1007/s10815-020-01752-3
pmc: PMC7244676
doi:
Substances chimiques
Gonadotropins
0
Banques de données
ClinicalTrials.gov
['NCT03836118']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1195-1201Références
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