Neural correlates of working memory function in pediatric cancer survivors treated with chemotherapy: an fMRI study.
acute lymphoblastic leukemia
blood oxygenation level dependent (BOLD) fMRI
chemobrain
cognitive impairment
cognitive late effects
functional MRI
n-back tasks
Journal
NMR in biomedicine
ISSN: 1099-1492
Titre abrégé: NMR Biomed
Pays: England
ID NLM: 8915233
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
28
12
2019
revised:
01
03
2020
accepted:
02
03
2020
pubmed:
28
3
2020
medline:
9
7
2021
entrez:
28
3
2020
Statut:
ppublish
Résumé
The goal of this study is to investigate the neural correlates of working memory function associated with chemotherapy in pediatric cancer survivors using event-related functional MRI (fMRI) analysis. Fifteen pediatric cancer survivors treated with chemotherapy and 15 healthy controls were studied. Blood oxygenation level dependent (BOLD) fMRI was acquired. A visual n-back task was used to test working memory function during the fMRI scan. Responses were recorded via an MRI compatible button box for analysis. fMRI scans were analyzed using statistical parametric mapping software. All statistics were corrected for multiple comparisons by false discovery rate, with p < 0.05 as significance. Patients however gave more incorrect responses (p < 0.05), more no responses (p < 0.05), and longer response times (p < 0.05) compared with healthy controls. Correct responses generated significantly lower BOLD responses in the posterior cingulate for pediatric cancer survivors compared with controls (p < 0.05). Incorrect responses generated significantly greater BOLD responses in the angular gyrus in survivors (p < 0.05), and no response trials generated greater BOLD responses within the superior parietal lobule (p < 0.05) compared with controls. Working memory impairment appears to be due to an inability to manipulate information and to retrieve information from memory. The ability to delineate the affected neural circuits associated with chemotherapy-induced cognitive impairment could inform treatment strategies, identify patients at high risk of developing cognitive deficits, and pre-emptively tailor behavioral enrichment to overcome specific cognitive deficits.
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e4296Informations de copyright
© 2020 John Wiley & Sons, Ltd.
Références
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7-34.
Hardy SJ, Krull KR, Wefel JS, Janelsins M. Cognitive changes in cancer survivors. Am Soc Clin Oncol Educ Book. 2018;38:795-806.
Peterson CC, Johnson CE, Ramirez LY, et al. A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008;51(1):99-104.
Moore BD III. Neurocognitive outcomes in survivors of childhood cancer. J Pediatr Psychol. 2005;30(1):51-63.
Buizer AI, de Sonneville LM, Veerman AJ. Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: a critical review of the literature. Pediatr Blood Cancer. 2009;52(4):447-454.
Brown RT, Madan-Swain A, Pais R, Lambert RG, Sexson S, Ragab A. Chemotherapy for acute lymphocytic leukemia: cognitive and academic sequelae. J Pediatr. 1992;121(6):885-889.
Sleurs C, Deprez S, Emsell L, Lemiere J, Uyttebroeck A. Chemotherapy-induced neurotoxicity in pediatric solid non-CNS tumor patients: an update on current state of research and recommended future directions. Crit Rev Oncol Hematol. 2016;103:37-48. PMID 27233118
Hearps S, Seal M, Anderson V, et al. The relationship between cognitive and neuroimaging outcomes in children treated for acute lymphoblastic leukemia with chemotherapy only: a systematic review. Pediatr Blood Cancer. 2017;64(2):225-233.
Bona K, Dussel V, Orellana L, et al. Economic impact of advanced pediatric cancer on families. J Pain Symptom Manage. 2014;47(3):594-603.
Aluise CD, Sultana R, Tangpong J, et al. Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction. Adv Exp Med Biol. 2010;678:147-156.
Jim HS, Phillips KM, Chait S, et al. Meta-analysis of cognitive functioning in breast cancer survivors previously treated with standard-dose chemotherapy. J Clin Oncol. 2012;30(29):3578-3587.
Hermelink K. Chemotherapy and cognitive function in breast cancer patients: the so-called chemo brain. J Natl Cancer Inst Monogr. 2015;2015(51):67-69.
de Ruiter MB, Reneman L, Boogerd W, et al. Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: converging results from multimodal magnetic resonance imaging. Hum Brain Mapp. 2012;33(12):2971-2983.
Hodgson KD, Hutchinson AD, Wilson CJ, Nettelbeck T. A meta-analysis of the effects of chemotherapy on cognition in patients with cancer. Cancer Treat Rev. 2013;39(3):297-304.
van der Plas E, Schachar RJ, Hitzler J, et al. Brain structure, working memory and response inhibition in childhood leukemia survivors. Brain Behav. 2017;7(2):e00621.
Genschaft M, Huebner T, Plessow F, et al. Impact of chemotherapy for childhood leukemia on brain morphology and function. PLoS ONE. 2013;8(11):e78599.
Anderson FS, Kunin-Batson AS. Neurocognitive late effects of chemotherapy in children: the past 10 years of research on brain structure and function. Pediatr Blood Cancer. 2009;52(2):159-164.
Tamnes CK, Zeller B, Amlien IK, et al. Cortical surface area and thickness in adult survivors of pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2015;62(6):1027-1034.
Wang L, Zou L, Chen Q, et al. Gray matter structural network disruptions in survivors of acute lymphoblastic leukemia with chemotherapy treatment. Acad Radiol. 2019;27(3):e27-e34.
Reddick WE, Taghipour DJ, Glass JO, et al. Prognostic factors that increase the risk for reduced white matter volumes and deficits in attention and learning for survivors of childhood cancers. Pediatr Blood Cancer. 2014;61(6):1074-1079.
Dellani PR, Eder S, Gawehn J, et al. Late structural alterations of cerebral white matter in long-term survivors of childhood leukemia. J Magn Reson Imaging. 2008;27(6):1250-1255.
Edelmann MN, Krull KR, Liu W, et al. Diffusion tensor imaging and neurocognition in survivors of childhood acute lymphoblastic leukaemia. Brain. 2014;137(Pt 11):2973-2983.
Sabin ND, Cheung YT, Reddick WE, et al. The impact of persistent leukoencephalopathy on brain white matter microstructure in long-term survivors of acute lymphoblastic leukemia treated with chemotherapy only. Am J Neuroradiol. 2018;39(10):1919-1925.
Sleurs C, Lemiere J, Christiaens D, et al. Advanced MR diffusion imaging and chemotherapy-related changes in cerebral white matter microstructure of survivors of childhood bone and soft tissue sarcoma? Hum Brain Mapp. 2018;39(8):3375-3387.
Kesler SR, Gugel M, Pritchard-Berman M, et al. Altered resting state functional connectivity in young survivors of acute lymphoblastic leukemia. Pediatr Blood Cancer. 2014;61(7):1295-1299.
Billiet T, Elens I, Sleurs C, et al. Brain connectivity and cognitive flexibility in nonirradiated adult survivors of childhood leukemia. J Natl Cancer Inst. 2018;110(8):905-913.
Robinson KE, Livesay KL, Campbell LK, et al. Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses. Pediatr Blood Cancer. 2010;54(4):585-590.
Edelmann MN, Ogg RJ, Scoggins MA, et al. Dexamethasone exposure and memory function in adult survivors of childhood acute lymphoblastic leukemia: a report from the SJLIFE cohort. Pediatr Blood Cancer. 2013;60(11):1778-1784.
Krull KR, Cheung YT, Liu W, et al. Chemotherapy pharmacodynamics and neuroimaging and neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia. J Clin Oncol. 2016;34(22):2644-2653.
Barch DM, Burgess GC, Harms MP, et al. Function in the human connectome: task-fMRI and individual differences in behavior. NeuroImage. 2013;80:169-189.
Leech R, Sharp DJ. The role of the posterior cingulate cortex in cognition and disease. Brain. 2014;137(Pt 1):12-32.
Seghier ML. The angular gyrus: multiple functions and multiple subdivisions. Neuroscientist. 2013;19(1):43-61.
Koenigs M, Barbey AK, Postle BR, Grafman J. Superior parietal cortex is critical for the manipulation of information in working memory. J Neurosci. 2009;29(47):14980-14986.
Kingma A, van Dommelen RI, Mooyaart EL, Wilmink JT, Deelman BG, Kamps WA. Slight cognitive impairment and magnetic resonance imaging abnormalities but normal school levels in children treated for acute lymphoblastic leukemia with chemotherapy only. J Pediatr. 2001;139(3):413-420.
Monje M, Thomason ME, Rigolo L, et al. Functional and structural differences in the hippocampus associated with memory deficits in adult survivors of acute lymphoblastic leukemia. Pediatr Blood Cancer. 2013;60(2):293-300.