A polygenic score for age-at-first-birth predicts disinhibition.
Reproductive behavior
genetics
longitudinal
risk-taking
self-control
Journal
Journal of child psychology and psychiatry, and allied disciplines
ISSN: 1469-7610
Titre abrégé: J Child Psychol Psychiatry
Pays: England
ID NLM: 0375361
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
accepted:
03
02
2020
pubmed:
29
3
2020
medline:
30
9
2021
entrez:
29
3
2020
Statut:
ppublish
Résumé
A recent genome-wide association study identified molecular-genetic associations with age-at-first-birth. However, the meaning of these genetic discoveries is unclear. Drawing on evidence linking early pregnancy with disinhibitory behavior, we tested the hypothesis that genetic discoveries for age-at-first-birth predict disinhibition. We included participants with genotype data from the two-decade-long Environmental Risk (E-Risk) Study (N = 1,999) and the four-decade-long Dunedin Study (N = 918). We calculated a genome-wide polygenic score for age-at-first-birth and tested whether it was associated with a range of disinhibitory outcomes across the life course, including low childhood self-control; risk for externalizing psychopathology; officially recorded criminal offending; substance dependence; informant reports of disinhibitory problems; and number of lifetime sexual partners. We further tested whether associations were attributable to accelerated pubertal maturation. In both cohorts, the age-at-first-birth polygenic score predicted low childhood self-control, externalizing psychopathology, officially recorded criminal offending, substance dependence, and number of sexual partners. Associations were modest, but robust across replication. Childhood disinhibition partly mediated associations between the polygenic score and reproductive behaviors. In contrast, associations were not attributable to accelerated pubertal timing. Genomic discoveries for age-at-first-birth are about more than reproductive biology: They provide insight into the disinhibitory traits and behaviors that accompany early parenthood. Age-at-first-birth is a useful proxy phenotype for researchers interested in disinhibition. Further, interventions that improve self-regulation abilities may benefit young parents and their children.
Sections du résumé
BACKGROUND
A recent genome-wide association study identified molecular-genetic associations with age-at-first-birth. However, the meaning of these genetic discoveries is unclear. Drawing on evidence linking early pregnancy with disinhibitory behavior, we tested the hypothesis that genetic discoveries for age-at-first-birth predict disinhibition.
METHODS
We included participants with genotype data from the two-decade-long Environmental Risk (E-Risk) Study (N = 1,999) and the four-decade-long Dunedin Study (N = 918). We calculated a genome-wide polygenic score for age-at-first-birth and tested whether it was associated with a range of disinhibitory outcomes across the life course, including low childhood self-control; risk for externalizing psychopathology; officially recorded criminal offending; substance dependence; informant reports of disinhibitory problems; and number of lifetime sexual partners. We further tested whether associations were attributable to accelerated pubertal maturation.
RESULTS
In both cohorts, the age-at-first-birth polygenic score predicted low childhood self-control, externalizing psychopathology, officially recorded criminal offending, substance dependence, and number of sexual partners. Associations were modest, but robust across replication. Childhood disinhibition partly mediated associations between the polygenic score and reproductive behaviors. In contrast, associations were not attributable to accelerated pubertal timing.
CONCLUSIONS
Genomic discoveries for age-at-first-birth are about more than reproductive biology: They provide insight into the disinhibitory traits and behaviors that accompany early parenthood. Age-at-first-birth is a useful proxy phenotype for researchers interested in disinhibition. Further, interventions that improve self-regulation abilities may benefit young parents and their children.
Identifiants
pubmed: 32220142
doi: 10.1111/jcpp.13224
pmc: PMC7529719
mid: NIHMS1589250
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1349-1359Subventions
Organisme : NICHD NIH HHS
ID : P2C HD065563
Pays : United States
Organisme : Medical Research Council
ID : P005918
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R01 HD077482
Pays : United States
Organisme : NICHD NIH HHS
ID : HD007376
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007376
Pays : United States
Organisme : NICHD NIH HHS
ID : HD077482
Pays : United States
Organisme : Medical Research Council
ID : G1002190
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : AG032282
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032282
Pays : United States
Informations de copyright
© 2020 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.
Références
Adv Child Dev Behav. 2012;42:113-52
pubmed: 22675905
Science. 2018 Jan 26;359(6374):424-428
pubmed: 29371463
Soc Psychiatry Psychiatr Epidemiol. 2015 May;50(5):679-93
pubmed: 25835958
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Child Dev. 2019 Oct 27;:
pubmed: 31657015
PLoS Genet. 2009 Jun;5(6):e1000529
pubmed: 19543373
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13790-4
pubmed: 25201988
Psychol Sci. 2016 Jul;27(7):957-72
pubmed: 27251486
Demography. 2018 Aug;55(4):1245-1267
pubmed: 29978338
J Child Psychol Psychiatry. 2002 Sep;43(6):727-42
pubmed: 12236608
Eur J Popul. 2013 Feb;29(1):1-38
pubmed: 23440941
Nat Genet. 2019 Feb;51(2):237-244
pubmed: 30643251
Nat Hum Behav. 2019 May;3(5):513-525
pubmed: 30962613
Dev Rev. 2007 Jun;27(2):151-171
pubmed: 20740062
Lancet Psychiatry. 2016 Mar;3(3):280-96
pubmed: 26905481
J Adolesc Health. 2015 Jun;56(6):586-98
pubmed: 25636818
Nature. 2012 Nov 1;491(7422):56-65
pubmed: 23128226
Nucleic Acids Res. 2001 Jan 1;29(1):308-11
pubmed: 11125122
Bioinformatics. 2015 May 1;31(9):1466-8
pubmed: 25550326
Nat Neurosci. 2018 Dec;21(12):1656-1669
pubmed: 30482948
Nat Hum Behav. 2019 Jun;3(6):576-586
pubmed: 30962612
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2693-8
pubmed: 21262822
PLoS Genet. 2013 Mar;9(3):e1003348
pubmed: 23555274
Pediatrics. 2014 Jan;133(1):114-22
pubmed: 24298010
Mol Psychiatry. 2016 Mar;21(3):437-43
pubmed: 25754083
JAMA Pediatr. 2018 Jun 1;172(6):566-575
pubmed: 29710097
Nat Genet. 2016 Dec;48(12):1462-1472
pubmed: 27798627
Psychol Sci. 2018 May;29(5):791-803
pubmed: 29513605
Pediatrics. 2005 Jul;116(1):281-6
pubmed: 15995071
Psychol Bull. 2014 Mar;140(2):434-65
pubmed: 23855958