Non-canonical roles of connexins.

Animals Cell Death Cell Proliferation Connexins / metabolism Humans
Cell death Cell growth Connexin

Journal

Progress in biophysics and molecular biology
ISSN: 1873-1732
Titre abrégé: Prog Biophys Mol Biol
Pays: England
ID NLM: 0401233

Informations de publication

Date de publication:
07 2020
Historique:
received: 18 12 2019
revised: 06 03 2020
accepted: 16 03 2020
pubmed: 30 3 2020
medline: 28 5 2021
entrez: 30 3 2020
Statut: ppublish

Résumé

Gap junctions mediate cellular communication and homeostasis by controlling the intercellular exchange of small and hydrophilic molecules and ions. Gap junction channels are formed by the docking of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin subunits. Connexin proteins as such can also control the cellular life cycle independent of their channel activities. This has been most demonstrated in the context of cell growth and cell death. Different mechanisms are involved mainly related to direct interaction with cell growth or cell death regulators, but also implying effects on the expression of cell growth and cell death regulators. The present paper focuses on these atypical roles of connexin proteins.

Identifiants

DOI: 10.1016/j.pbiomolbio.2020.03.002 PMID: 32220599
pubmed: 32220599
pii: S0079-6107(20)30024-9
doi: 10.1016/j.pbiomolbio.2020.03.002
pii:
doi:

Substances chimiques

Connexins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

35-41

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Raf Van Campenhout (R)

Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium.

Axelle Cooreman (A)

Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium.

Kaat Leroy (K)

Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium.

Olga M Rusiecka (OM)

Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.

Pieter Van Brantegem (P)

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

Pieter Annaert (P)

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

Serge Muyldermans (S)

Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.

Nick Devoogdt (N)

In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium.

Bruno Cogliati (B)

Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.

Brenda R Kwak (BR)

Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.

Mathieu Vinken (M)

Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: mathieu.vinken@vub.be.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Non-canonical roles of connexins.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Non-canonical roles of connexins.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Non-canonical roles of connexins.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Connexines › Non-canonical roles of connexins.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Non-canonical roles of connexins.