Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use.
Antibiotic
Antivirulence
Bacteriophage
Genetics
Genomics
Microbiome
Vaccine
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
ISSN: 1469-0691
Titre abrégé: Clin Microbiol Infect
Pays: England
ID NLM: 9516420
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
10
12
2019
revised:
19
02
2020
accepted:
22
02
2020
pubmed:
30
3
2020
medline:
24
6
2021
entrez:
30
3
2020
Statut:
ppublish
Résumé
This review follows on from the International Conference on One Health Antimicrobial Resistance (ICOHAR 2019), where strategies to improve the fundamental understanding and management of antimicrobial resistance at the interface between humans, animals and the environment were discussed. This review identifies alternatives to antimicrobials in a One Health context, noting how advances in genomic technologies are assisting their development and enabling more targeted use of antimicrobials. Key articles on the use of microbiota modulation, livestock breeding and gene editing, vaccination, antivirulence strategies and bacteriophage therapy are discussed. Antimicrobials are central for disease control, but reducing their use is paramount as a result of the rise of transmissible antimicrobial resistance. This review discusses antimicrobial alternatives in the context of improved understanding of fundamental host-pathogen and microbiota interactions using genomic tools. Host and microbial genomics and other novel technologies play an important role in devising disease control strategies for healthier animals and humans that in turn reduce our reliance on antimicrobials.
Sections du résumé
BACKGROUND
BACKGROUND
This review follows on from the International Conference on One Health Antimicrobial Resistance (ICOHAR 2019), where strategies to improve the fundamental understanding and management of antimicrobial resistance at the interface between humans, animals and the environment were discussed.
OBJECTIVE
OBJECTIVE
This review identifies alternatives to antimicrobials in a One Health context, noting how advances in genomic technologies are assisting their development and enabling more targeted use of antimicrobials.
SOURCES
METHODS
Key articles on the use of microbiota modulation, livestock breeding and gene editing, vaccination, antivirulence strategies and bacteriophage therapy are discussed.
CONTENT
BACKGROUND
Antimicrobials are central for disease control, but reducing their use is paramount as a result of the rise of transmissible antimicrobial resistance. This review discusses antimicrobial alternatives in the context of improved understanding of fundamental host-pathogen and microbiota interactions using genomic tools.
IMPLICATIONS
CONCLUSIONS
Host and microbial genomics and other novel technologies play an important role in devising disease control strategies for healthier animals and humans that in turn reduce our reliance on antimicrobials.
Identifiants
pubmed: 32220638
pii: S1198-743X(20)30132-4
doi: 10.1016/j.cmi.2020.02.028
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1617-1621Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M028305/1
Pays : United Kingdom
Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.