Dicer up-regulation by inhibition of specific proteolysis in differentiating monocytic cells.
Cell Differentiation
Cells, Cultured
DEAD-box RNA Helicases
/ genetics
Dinoprostone
/ pharmacology
Hematopoiesis
Humans
Lipopolysaccharides
/ pharmacology
MicroRNAs
/ genetics
Monocytes
/ cytology
Prostaglandin-E Synthases
/ genetics
Proteolysis
Receptors, Prostaglandin E, EP2 Subtype
/ metabolism
Receptors, Prostaglandin E, EP4 Subtype
/ metabolism
Ribonuclease III
/ genetics
Zymosan
/ pharmacology
PGE2
macrophage
miRNA
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
14 04 2020
14 04 2020
Historique:
pubmed:
30
3
2020
medline:
22
7
2020
entrez:
30
3
2020
Statut:
ppublish
Résumé
Dicer is a ribonuclease III enzyme in biosynthesis of micro-RNAs (miRNAs). Here we describe a regulation of Dicer expression in monocytic cells, based on proteolysis. In undifferentiated Mono Mac 6 (MM6) cells, full-length Dicer was undetectable; only an ∼50-kDa fragment appeared in Western blots. However, when MM6 cells were treated with zymosan or LPS during differentiation with TGF-β and 1,25diOHvitD3, full-length Dicer became abundant together with varying amounts of ∼170- and ∼50-kDa Dicer fragments. Mass spectrometry identified the Dicer fragments and showed cleavage about 450 residues upstream from the C terminus. Also, PGE
Identifiants
pubmed: 32220961
pii: 1916249117
doi: 10.1073/pnas.1916249117
pmc: PMC7165444
doi:
Substances chimiques
Lipopolysaccharides
0
MicroRNAs
0
Receptors, Prostaglandin E, EP2 Subtype
0
Receptors, Prostaglandin E, EP4 Subtype
0
Zymosan
9010-72-4
DICER1 protein, human
EC 3.1.26.3
Ribonuclease III
EC 3.1.26.3
DEAD-box RNA Helicases
EC 3.6.4.13
PTGES protein, human
EC 5.3.99.3
Prostaglandin-E Synthases
EC 5.3.99.3
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8573-8583Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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