Pediatric Community-Acquired Bone and Joint Staphylococcus Aureus Infections In Europe: Severe Infections are Associated to Panton-Valentine Leucocidin Presence.
Adolescent
Arthritis, Infectious
/ epidemiology
Bacterial Toxins
/ genetics
Bone and Bones
/ microbiology
Child
Child, Preschool
Community-Acquired Infections
/ epidemiology
Europe
/ epidemiology
Exotoxins
/ genetics
Humans
Infant
Infant, Newborn
Joints
/ microbiology
Leukocidins
/ genetics
Methicillin-Resistant Staphylococcus aureus
/ pathogenicity
Prospective Studies
Severity of Illness Index
Staphylococcal Infections
/ epidemiology
Staphylococcus aureus
/ genetics
Virulence Factors
Journal
The Pediatric infectious disease journal
ISSN: 1532-0987
Titre abrégé: Pediatr Infect Dis J
Pays: United States
ID NLM: 8701858
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
pubmed:
30
3
2020
medline:
7
4
2021
entrez:
30
3
2020
Statut:
ppublish
Résumé
To analyze host and pathogen factors related to disease severity of community-acquired bone and joint infections in children, a cohort of pediatric patients was prospectively recruited from 13 centers in 7 European countries. A total of 85 children were included, 11 (13%) had a severe infection. Panton-Valentine leukocidin-positive isolates were 17%, and 6% of the isolates were methicillin-resistant Staphylococcus aureus. Multivariate analysis identified Panton-Valentine leukocidin presence (adjusted odds ratio, 12.6; P = 0.01) as the only factor independently associated with severe outcome, regardless of methicillin resistance.
Identifiants
pubmed: 32221170
doi: 10.1097/INF.0000000000002640
pii: 00006454-202006000-00023
doi:
Substances chimiques
Bacterial Toxins
0
Exotoxins
0
Leukocidins
0
Panton-Valentine leukocidin
0
Virulence Factors
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e73-e76Références
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