Presepsin and Midregional Proadrenomedullin in Pediatric Oncologic Patients with Febrile Neutropenia.
Adrenomedullin
Presepsin
fever
malignancies
mr-proADM
neutropenia
oncologic
pediatric
Journal
Laboratory medicine
ISSN: 1943-7730
Titre abrégé: Lab Med
Pays: England
ID NLM: 0250641
Informations de publication
Date de publication:
02 Nov 2020
02 Nov 2020
Historique:
pubmed:
30
3
2020
medline:
22
7
2021
entrez:
30
3
2020
Statut:
ppublish
Résumé
In this study, we investigated the roles of presepsin (PSP) and midregional proadrenomedullin (mr-proADM) in children with febrile neutropenia (FN) due to chemotherapy. We assessed 36 FN episodes in 26 children. Patients were classified into bacteremia (B) and fever of unknown origin (FUO) groups. We evaluated PSP and mr-proADM at admission (T0), after 24/48 h (T1), and after 5 days (T2). PSP and mr-proADM levels were elevated at T0 and significantly decreased at T2. mr-proADM levels did not significantly differ between the B and FUO groups. PSP levels significantly differed between the B and FUO groups only at T1. Both PSP and mr-proADM levels at T0 were a predictor of length of hospital stay but not of the duration of fever. Finally, receiver operating characteristic curve analysis showed that PSP and mr-proADM had low diagnostic accuracy for blood culture positivity. PSP and mr-proADM display poor clinical usefulness for FN in oncologic children.
Identifiants
pubmed: 32221546
pii: 5813004
doi: 10.1093/labmed/lmaa011
doi:
Substances chimiques
Biomarkers
0
Lipopolysaccharide Receptors
0
Peptide Fragments
0
Protein Precursors
0
presepsin protein, human
0
proadrenomedullin
0
Adrenomedullin
148498-78-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
585-591Informations de copyright
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