Myosin-18B Promotes Mechanosensitive CaMKK2-AMPK-VASP Regulation of Contractile Actin Stress Fibers.
Biological Sciences
Cell Biology
Functional Aspects of Cell Biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
24 Apr 2020
24 Apr 2020
Historique:
received:
27
11
2019
revised:
06
02
2020
accepted:
06
03
2020
pubmed:
31
3
2020
medline:
31
3
2020
entrez:
31
3
2020
Statut:
ppublish
Résumé
Actin stress fibers guide cell migration and morphogenesis. During centripetal flow, actin transverse arcs fuse accompanied by the formation of myosin II stacks to generate mechanosensitive actomyosin bundles. However, whether myosin II stack formation plays a role in cell mechano-sensing has remained elusive. Myosin-18B is a "glue" molecule for assembling myosin II stacks. By examining actin networks and traction forces, we find that cells abolishing myosin-18B resemble Ca
Identifiants
pubmed: 32222698
pii: S2589-0042(20)30159-0
doi: 10.1016/j.isci.2020.100975
pmc: PMC7109629
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100975Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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