The β-Secretase BACE1 in Alzheimer's Disease.

Alzheimer Disease / drug therapy Amyloid Precursor Protein Secretases Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Aspartic Acid Endopeptidases / genetics Humans Mice Mice, Knockout
Alzheimer’s disease BACE1 inhibitors Biomarkers Clinical trials Soluble amyloid Synaptic

Journal

Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264

Informations de publication

Date de publication:
15 04 2021
Historique:
received: 08 08 2019
revised: 29 01 2020
accepted: 05 02 2020
pubmed: 1 4 2020
medline: 24 4 2021
entrez: 1 4 2020
Statut: ppublish

Résumé

BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), including Aβ

Identifiants

DOI: 10.1016/j.biopsych.2020.02.001 PMID: 32223911 PMC: PMC7533042
pubmed: 32223911
pii: S0006-3223(20)30063-9
doi: 10.1016/j.biopsych.2020.02.001
pmc: PMC7533042
mid: NIHMS1631119
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Amyloid beta-Protein Precursor 0
Bace2 protein, mouse 0
Amyloid Precursor Protein Secretases EC 3.4.-
Aspartic Acid Endopeptidases EC 3.4.23.-
BACE1 protein, human EC 3.4.23.46
Bace1 protein, mouse EC 3.4.23.46

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

745-756

Subventions

Organisme : Medical Research Council
ID : MR/L501542/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-0907
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701075
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS074256
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG046929
Pays : United States
Organisme : Medical Research Council
ID : MR/N026004/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0901254
Pays : United Kingdom

Informations de copyright

Copyright © 2020 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

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Auteurs

Harald Hampel (H)

Neurology Business Group, Eisai Inc., Woodcliff Lake, New Jersey; Sorbonne University, GRC No. 21, Alzheimer Precision Medicine, Pitié-Salpêtrière Hospital, Paris, France. Electronic address: harald_hampel@eisai.com.

Robert Vassar (R)

Department of Neurology, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Bart De Strooper (B)

Department of Neurosciences, KU Leuven, Leuven, Belgium; Centre for Brain and Disease Research, VIB (Flanders Institute for Biotechnology), Leuven, Belgium; Dementia Research Institute, University College London, London, United Kingdom.

John Hardy (J)

Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Queen Square Institute of Neurology, University College London, London, United Kingdom.

Michael Willem (M)

Chair of Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig Maximilians University Munich, Munich, Germany.

Neeraj Singh (N)

Department of Neuroscience, University of Connecticut Health, Farmington, Connecticut.

John Zhou (J)

Department of Neuroscience, University of Connecticut Health, Farmington, Connecticut.

Riqiang Yan (R)

Department of Neuroscience, University of Connecticut Health, Farmington, Connecticut.

Eugeen Vanmechelen (E)

ADx NeuroSciences NV, Ghent, Belgium.

Ann De Vos (A)

ADx NeuroSciences NV, Ghent, Belgium.

Robert Nisticò (R)

Laboratory of Neuropharmacology, EBRI Rita Levi-Montalcini Foundation, Rome, Italy; School of Pharmacy, Department of Biology, University of Rome "Tor Vergata," Rome, Italy.

Massimo Corbo (M)

Department of Neurorehabilitation Sciences, Casa Cura Policlinico, Milan, Italy.

Bruno Pietro Imbimbo (BP)

Department of Research and Development, Chiesi Farmaceutici, Parma, Italy.

Johannes Streffer (J)

Reference Center for Biological Markers of Dementia, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; UCB Biopharma SPRL, Braine-l'Alleud, Belgium.

Iryna Voytyuk (I)

Department of Neurosciences, KU Leuven, Leuven, Belgium; Centre for Brain and Disease Research, VIB (Flanders Institute for Biotechnology), Leuven, Belgium; ALBORADA Drug Discovery Institute, University of Cambridge, Cambridge, United Kingdom.

Maarten Timmers (M)

Reference Center for Biological Markers of Dementia, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Janssen Research and Development, a division of Janssen Pharmaceutica, Beerse, Belgium.

Amir Abbas Tahami Monfared (AA)

Neurology Business Group, Eisai Inc., Woodcliff Lake, New Jersey; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

Michael Irizarry (M)

Neurology Business Group, Eisai Inc., Woodcliff Lake, New Jersey.

Bruce Albala (B)

Neurology Business Group, Eisai Inc., Woodcliff Lake, New Jersey.

Akihiko Koyama (A)

Neurology Business Group, Eisai Inc., Woodcliff Lake, New Jersey.

Naoto Watanabe (N)

Eisai Company Ltd., Tokyo, Japan.

Teiji Kimura (T)

Eisai Company Ltd., Tokyo, Japan.

Lisa Yarenis (L)

Neurology Business Group, Eisai Inc., Woodcliff Lake, New Jersey.

Simone Lista (S)

Sorbonne University, GRC No. 21, Alzheimer Precision Medicine, Pitié-Salpêtrière Hospital, Paris, France; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, Paris, France; Brain & Spine Institute, INSERM U 1127, CNRS UMR 7225, Paris, France.

Lynn Kramer (L)

Neurology Business Group, Eisai Inc., Woodcliff Lake, New Jersey.

Andrea Vergallo (A)

Neurology Business Group, Eisai Inc., Woodcliff Lake, New Jersey; Sorbonne University, GRC No. 21, Alzheimer Precision Medicine, Pitié-Salpêtrière Hospital, Paris, France; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, Paris, France; Brain & Spine Institute, INSERM U 1127, CNRS UMR 7225, Paris, France. Electronic address: andrea_vergallo@eisai.com.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › The β-Secretase BACE1 in Alzheimer's Disease.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Amyloid precursor protein secretases › The β-Secretase BACE1 in Alzheimer's Disease.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › The β-Secretase BACE1 in Alzheimer's Disease.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Protéase nexines › Précurseur de la protéine bêta-amyloïde › The β-Secretase BACE1 in Alzheimer's Disease.
questionsmedicales.fr › Eucaryotes › Animaux › The β-Secretase BACE1 in Alzheimer's Disease.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Aspartic acid endopeptidases › The β-Secretase BACE1 in Alzheimer's Disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The β-Secretase BACE1 in Alzheimer's Disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The β-Secretase BACE1 in Alzheimer's Disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › The β-Secretase BACE1 in Alzheimer's Disease.