Pancreatic Neuroendocrine Neoplasms: Does Sex Matter?

Biomarkers, Tumor / metabolism Female Humans Male Neuroendocrine Tumors / pathology Pancreatic Neoplasms / pathology Prognosis Sex Characteristics
epidemiology pancreatic neuroendocrine neoplasms sex sex difference

Journal

Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516

Informations de publication

Date de publication:
09 2020
Historique:
received: 12 11 2019
revised: 19 02 2020
accepted: 21 02 2020
pubmed: 1 4 2020
medline: 10 8 2021
entrez: 1 4 2020
Statut: ppublish

Résumé

Genetic and molecular disparities between men and women have a role in the differing incidence, pathophysiology, clinical signs, and treatment outcome of several cancers. Sex differences in cancer incidence are attributed to regulation at the genetic/molecular level and to sex hormones that in turn modulate gene expression in various cancers. Sex differences in the incidence of cancer, its aggressiveness, and the disease prognosis have been reported for several types of cancer but little is known for pancreatic neuroendocrine neoplasms (PNENs). The aim of this Opinion article is to provide an overview of sex differences in PNENs in terms of epidemiology, pathophysiology, treatment responses, prognosis, and survival. This overview might allow better tailoring of the management of PNENs.

Identifiants

DOI: 10.1016/j.tem.2020.02.010 PMID: 32223919
pubmed: 32223919
pii: S1043-2760(20)30052-7
doi: 10.1016/j.tem.2020.02.010
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

631-641

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Giovanna Muscogiuri (G)

Endocrinology Unit, Department of Clinical Medicine and Surgery, University 'Federico II', Naples, Italy. Electronic address: giovanna.muscogiuri@gmail.com.

Luigi Barrea (L)

Endocrinology Unit, Department of Clinical Medicine and Surgery, University 'Federico II', Naples, Italy.

Tiziana Feola (T)

Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy.

Marco Gallo (M)

Department of Medical Sciences, Oncological Endocrinology Unit, University of Turin, Turin, Italy.

Erika Messina (E)

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Mary Anna Venneri (MA)

Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy.

Antongiulio Faggiano (A)

Department of Experimental Medicine, 'Sapienza' University of Rome, Rome, Italy.

Annamaria Colao (A)

Endocrinology Unit, Department of Clinical Medicine and Surgery, University 'Federico II', Naples, Italy.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Pancreatic Neuroendocrine Neoplasms: Does Sex Matter?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pancreatic Neuroendocrine Neoplasms: Does Sex Matter?
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Pancreatic Neuroendocrine Neoplasms: Does Sex Matter?
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Pancreatic Neuroendocrine Neoplasms: Does Sex Matter?
questionsmedicales.fr › Diagnostic › Pronostic › Pancreatic Neuroendocrine Neoplasms: Does Sex Matter?
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Pancreatic Neuroendocrine Neoplasms: Does Sex Matter?