Knockout of hyaluronidase Spam1 reduces age-related bone and cartilage changes in mouse knee.

Animals Cartilage Hyaluronoglucosaminidase Mice Mice, Knockout
Ageing Cartilage Hyaluronidase Spam1

Journal

Morphologie : bulletin de l'Association des anatomistes
ISSN: 1286-0115
Titre abrégé: Morphologie
Pays: France
ID NLM: 9814314

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 23 12 2019
revised: 11 02 2020
accepted: 02 03 2020
pubmed: 1 4 2020
medline: 31 8 2021
entrez: 1 4 2020
Statut: ppublish

Résumé

To investigate the role of Spam1 hyaluronidase in age-related bone and cartilage changes in the mouse knee. Spam1 Spam1 Spam1 knockout reduced significantly cartilage degradation in mouse knee whereas the chondrocyte expression of Hyal 1, Hyal 2 and Mmp13 was modified, suggesting a role of this hyaluronidase in cartilage metabolism.

Identifiants

DOI: 10.1016/j.morpho.2020.03.001 PMID: 32224028
pubmed: 32224028
pii: S1286-0115(20)30024-2
doi: 10.1016/j.morpho.2020.03.001
pii:
doi:

Substances chimiques

Hyaluronoglucosaminidase EC 3.2.1.35

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

151-157

Informations de copyright

Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Auteurs

S Lafont (S)

Pole of Morphology-Institut de recherche expérimentale et Clinique - Université Catholique de Louvain, Brussels, Belgium. Electronic address: sebastien.lafont@uclouvain.be.

Y Achouri (Y)

Institut de Duve, Université catholique de Louvain, Brussels, Belgium.

M Cardinal (M)

Pole of Morphology-Institut de recherche expérimentale et Clinique - Université Catholique de Louvain, Brussels, Belgium.

T Roels (T)

Pole of Morphology-Institut de recherche expérimentale et Clinique - Université Catholique de Louvain, Brussels, Belgium.

C de Ville de Goyet (C)

Pole of Morphology-Institut de recherche expérimentale et Clinique - Université Catholique de Louvain, Brussels, Belgium.

C Behets (C)

Pole of Morphology-Institut de recherche expérimentale et Clinique - Université Catholique de Louvain, Brussels, Belgium.

D Manicourt (D)

Pole of Systemic and Inflammatory Rheumatic Diseases-Institut de recherche expérimentale et Clinique - Université Catholique de Louvain, Brussels, Belgium.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Knockout of hyaluronidase Spam1 reduces...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Knockout of hyaluronidase Spam1 reduces...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Polysaccharide-lyases › Hyaluronoglucosaminidase › Knockout of hyaluronidase Spam1 reduces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Knockout of hyaluronidase Spam1 reduces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Knockout of hyaluronidase Spam1 reduces...