Hepatoprotective effects of total phenylethanoid glycosides from Acanthus ilicifolius L. against carbon tetrachloride-induced hepatotoxicity.

Acanthaceae / chemistry Alanine Transaminase / metabolism Animals Antioxidants / pharmacology Aspartate Aminotransferases / metabolism Carbon Tetrachloride / pharmacology Chemical and Drug Induced Liver Injury / drug therapy China Female Glucosides / pharmacology Glutathione / metabolism Glycosides / pharmacology Hepatocytes / drug effects Liver / drug effects Male Malondialdehyde / metabolism Mice Mice, Inbred C57BL Phenols / pharmacology Plant Extracts / pharmacology Protective Agents / pharmacology
Acanthus ilicifolius L. Antioxidant Hepatoprotective Total phenylethanoid glycosides

Journal

Journal of ethnopharmacology
ISSN: 1872-7573
Titre abrégé: J Ethnopharmacol
Pays: Ireland
ID NLM: 7903310

Informations de publication

Date de publication:
28 Jun 2020
Historique:
received: 04 08 2019
revised: 23 02 2020
accepted: 23 03 2020
pubmed: 1 4 2020
medline: 28 1 2021
entrez: 1 4 2020
Statut: ppublish

Résumé

Acanthus ilicifolius L. has been used as a folk medicine in the treatment of acute and chronic hepatitis in China for a long time. Phenylethanoid glycosides are one of main components in A. ilicifolius L. The aim of present study was to assess the hepatoprotective activities of total phenylethanoid glycosides from A. ilicifolius L. (APhGs) against carbon tetrachloride (CCl The APhGs was separated by resin column chromatography. The purity of total phenylethanoid glycosides was determined by UV-Vis spectrophotometry using acteoside as a standard. The hepatoprotective activities of APhGs against CCl The results showed that pre-administration of APhGs to mice decreased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in serum, and improved superoxide dismutase (SOD) activity and decreased malondialdehyde (MDA) level in serum and liver tissue induced by CCl Overall, total phenylethanoid glycosides from A. ilicifolius L. displayed promising hepatoprotective effects. These results offer a support for the medicine uses of A. ilicifolius L.

Identifiants

DOI: 10.1016/j.jep.2020.112795 PMID: 32224197
pubmed: 32224197
pii: S0378-8741(19)33099-5
doi: 10.1016/j.jep.2020.112795
pii:
doi:

Substances chimiques

Antioxidants 0
Glucosides 0
Glycosides 0
Phenols 0
Plant Extracts 0
Protective Agents 0
acteoside 3TGX09BD5B
Malondialdehyde 4Y8F71G49Q
Carbon Tetrachloride CL2T97X0V0
Aspartate Aminotransferases EC 2.6.1.1
Alanine Transaminase EC 2.6.1.2
Glutathione GAN16C9B8O

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112795

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interest.

Auteurs

Meng-Qi Zhang (MQ)

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Key Laboratory for Biosensor of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China.

Xia Ren (X)

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.

Qing Zhao (Q)

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.

Shi-Jun Yue (SJ)

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.

Xiu-Mei Fu (XM)

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China; College of Economics, Ocean University of China, Qingdao, 266100, China.

Xin Li (X)

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.

Kai-Xian Chen (KX)

Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology, Qingdao, 266237, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Yue-Wei Guo (YW)

Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology, Qingdao, 266237, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Chang-Lun Shao (CL)

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China. Electronic address: shaochanglun@ouc.edu.cn.

Chang-Yun Wang (CY)

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China. Electronic address: changyun@ouc.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Acanthaceae › Hepatoprotective effects of total...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Alanine transaminase › Hepatoprotective effects of total...
questionsmedicales.fr › Eucaryotes › Animaux › Hepatoprotective effects of total...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Hepatoprotective effects of total...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Aspartate aminotransferases › Hepatoprotective effects of total...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures chlorés › Tétrachloro-méthane › Hepatoprotective effects of total...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Hepatoprotective effects of total...
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Hepatoprotective effects of total...
questionsmedicales.fr › Glucides › Hétérosides › Glucosides › Hepatoprotective effects of total...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Hepatoprotective effects of total...
questionsmedicales.fr › Glucides › Hétérosides › Hepatoprotective effects of total...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Hepatoprotective effects of total...
questionsmedicales.fr › Système digestif › Foie › Hepatoprotective effects of total...
questionsmedicales.fr › Composés chimiques organiques › Aldéhydes › Malonaldéhyde › Hepatoprotective effects of total...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hepatoprotective effects of total...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Hepatoprotective effects of total...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Hepatoprotective effects of total...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Hepatoprotective effects of total...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Hepatoprotective effects of total...