Children with reported penicillin allergy: Public health impact and safety of delabeling.
Journal
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
ISSN: 1534-4436
Titre abrégé: Ann Allergy Asthma Immunol
Pays: United States
ID NLM: 9503580
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
03
12
2019
revised:
09
03
2020
accepted:
15
03
2020
pubmed:
1
4
2020
medline:
7
7
2020
entrez:
1
4
2020
Statut:
ppublish
Résumé
To review the relevant literature related to children with reported penicillin allergy and highlight the different ways in which children could be delabeled and to evaluate the public health impact that a penicillin allergy has for children. Data for this review were obtained via PubMed searches and then retrieval of articles from their respective journals for further review. Studies regarding the safety of different ways to evaluate penicillin allergy in children were identified via PubMed searches. Any study that reported different ways of testing (3-tier, direct oral challenge, 5-day oral challenges) were included. This same format was used when selecting relevant articg:les related to the costs, prescription patterns, and stewardship trends associated with a penicillin allergy label. This review found that penicillin allergy testing is a safe and effective way to delabel those with reported allergy. In children with low-risk allergy symptoms, a direct oral challenge approach may be optimal. In those children with a history of high-risk allergy symptoms, a 3-tiered approach is ideal. The review also found that there is a significant cost associated with reported penicillin allergy and that there are increased negative health benefits to those children with reported allergy. Penicillin allergy is overdiagnosed, often incorrectly, and the label is frequently first applied during childhood. Targeting children for the removal of the incorrect penicillin allergy label provides a mechanism to reduce the use of broader-spectrum and less effective antibiotics.
Identifiants
pubmed: 32224207
pii: S1081-1206(20)30156-3
doi: 10.1016/j.anai.2020.03.012
pmc: PMC7255916
mid: NIHMS1582586
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Penicillins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
558-565Subventions
Organisme : AHRQ HHS
ID : K12 HS026395
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010863
Pays : United States
Organisme : NHLBI NIH HHS
ID : K12 HL137943
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM115305
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI139021
Pays : United States
Organisme : NIAID NIH HHS
ID : R34 AI136815
Pays : United States
Informations de copyright
Copyright © 2020 American College of Allergy, Asthma & Immunology. All rights reserved.
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