Effect of breed body-size on leptin amniotic fluid concentrations at term pregnancy in dogs.
Amniotic Fluid
/ chemistry
Animals
Animals, Newborn
/ physiology
Birth Weight
Body Size
/ physiology
Cesarean Section
/ veterinary
Dogs
/ physiology
Female
Fetal Development
Leptin
/ analysis
Litter Size
/ physiology
Male
Organ Size
Parturition
Placenta
/ anatomy & histology
Pregnancy
Species Specificity
Amniotic fluid
Breed body-size
Dog
Leptin
Term pregnancy
Journal
Theriogenology
ISSN: 1879-3231
Titre abrégé: Theriogenology
Pays: United States
ID NLM: 0421510
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
19
08
2019
revised:
13
02
2020
accepted:
12
03
2020
pubmed:
1
4
2020
medline:
22
1
2021
entrez:
1
4
2020
Statut:
ppublish
Résumé
Because of the need to improve the knowledge about canine perinatology, and given the major role of fetal fluids in sustaining the course of pregnancy and fetal development, an in-depth analysis to better understand the role of some hormones in these compartments is essential. Among all, leptin is recognized to play a key role not only on the energetic homeostasis, but also at multiple levels, influencing the control of reproduction, food assumption and metabolism. Even if in humans and other species it is reported the presence of leptin receptors during fetal development, very little is known about the canine species, in which the role of leptin still needs to be fully understood. The present study aimed to assess the amniotic fluid leptin (AFL) concentrations at term pregnancy in healthy dogs, and to evaluate the possible influence played by breed body-size (after assessment of correlation with maternal bodyweight and placental weight), or other maternal (age, parity, and the so-called "litter effect") and neonatal (gender, birth weight, litter size) parameters on AFL concentrations, analyzed by ELISA test. The study was performed on 90 healthy, viable and normal weighted puppies, 39 small-sized (adult body weight < 10 kg) and 51 large-sized (adult body weight > 25 kg), born by 29 purebred, healthy bitches, submitted to elective Caesarean section because of breed-related or individual high risk for dystocia. The results showed that the mean AFL concentration in the small-sized puppies was significantly (p < 0.05) higher in comparison to large-sized puppies (867.48 vs 698.42 pg/ml), while all the other studied parameters did not show to influence AFL concentrations. In conclusions, the present study showed significant higher at term AFL concentrations in small-sized as compared to large-sized breeds, suggesting an influence of breed body-size on fetal metabolism, as previously reported for NEFA and IGF-I.
Identifiants
pubmed: 32224377
pii: S0093-691X(20)30187-4
doi: 10.1016/j.theriogenology.2020.03.021
pii:
doi:
Substances chimiques
Leptin
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-5Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.