Recent Advances in Studies of Skin Color and Skin Cancer.
cytidine as melanin inhibitor
leucocyte-tumor cell hybrids
melanin transfer
skin cancer
skin color
Journal
The Yale journal of biology and medicine
ISSN: 1551-4056
Titre abrégé: Yale J Biol Med
Pays: United States
ID NLM: 0417414
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
entrez:
1
4
2020
pubmed:
1
4
2020
medline:
24
4
2021
Statut:
epublish
Résumé
The relationship between skin color and skin cancer is well established: the less melanin in one's skin the greater the risk for developing skin cancer. This review is in two parts. First, we summarize the current understanding of the cutaneous pigmentary system and trace melanin from its synthesis in the pigment cell melanosomes through its transfer to keratinocytes. We also present new methods for reducing melanin content in hyper-pigmented areas of skin such as solar lentigenes, melasma, and post-inflammatory hyperpigmentation. Second, we present evidence that at least one mechanism for the development of metastatic melanoma and other solid tumors is fusion and hybridization of leucocytes such as macrophages with primary tumor cells. In this scenario, hybrid cells express both the chemotactic motility of the leucocyte and the de-regulated cell division of the tumor cell, causing the cells to migrate a deadly journey to lymph nodes, distant organs, and tissues.
Substances chimiques
Melanins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
69-80Informations de copyright
Copyright ©2020, Yale Journal of Biology and Medicine.
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