The Promise of JAK Inhibitors for Treatment of Sarcoidosis and Other Inflammatory Disorders with Macrophage Activation: A Review of the Literature.
Crohn’s disease
JAK inhibitor
Janus kinase
granuloma annulare
hemophagocytic lymphohistiocytosis
necrobiosis lipoidica
ruxolitinib
sarcoidosis
tofacitinib
Journal
The Yale journal of biology and medicine
ISSN: 1551-4056
Titre abrégé: Yale J Biol Med
Pays: United States
ID NLM: 0417414
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
entrez:
1
4
2020
pubmed:
1
4
2020
medline:
24
4
2021
Statut:
epublish
Résumé
Certain inflammatory disorders are characterized by macrophage activation and accumulation in tissue; sometimes leading to the formation of granulomas, as in sarcoidosis. These disorders are often difficult to treat and more effective, molecularly targeted therapies are needed. Recent work has shown that overproduction of inflammatory cytokines, such as interferon gamma (IFN-γ) leading to constitutive activation of the JAK-STAT pathway may be a conserved feature of these disorders. Use of JAK inhibitors, which can block these signals, has resulted in dramatic improvement in several patients with sarcoidosis. JAK inhibitors also appear to have activity in other inflammatory disorders with macrophage activation including hemophagocytic lymphohistiocystosis, Crohn's disease, granuloma annulare, and necrobiosis lipoidica. Here, we review the role of JAK dependent cytokines in macrophage activation and granuloma formation and the clinical evidence supporting the use of JAK inhibition in these disorders. Ongoing efforts to evaluate role of JAK inhibitors in these disorders is also discussed.
Substances chimiques
Janus Kinase Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
187-195Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
Copyright ©2020, Yale Journal of Biology and Medicine.
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