Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population.
dysbiosis
gut microbiota
hypertension
immune profile
inflammation
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
12
2019
accepted:
24
02
2020
entrez:
1
4
2020
pubmed:
1
4
2020
medline:
1
4
2020
Statut:
epublish
Résumé
Hypertension is a major global health challenge, as it represents the main risk factor for stroke and cardiovascular disease. It is a multifactorial clinical condition characterized by high and sustained levels of blood pressure, likely resulting from a complex interplay of endogenous and environmental factors. The gut microbiota has been strongly supposed to be involved but its role in hypertension is still poorly understood. In an attempt to fill this gap, here we characterized the microbial composition of fecal samples from 48 hypertensive and 32 normotensive Brazilian individuals by next-generation sequencing of the 16S rRNA gene. In addition, the cytokine production of peripheral blood samples was investigated to build an immunological profile of these individuals. We identified a dysbiosis of the intestinal microbiota in hypertensive subjects, featured by reduced biodiversity and distinct bacterial signatures compared with the normotensive counterpart. Along with a reduction in Bacteroidetes members, hypertensive individuals were indeed mainly characterized by increased proportions of
Identifiants
pubmed: 32226382
doi: 10.3389/fphar.2020.00258
pmc: PMC7080704
doi:
Types de publication
Journal Article
Langues
eng
Pagination
258Informations de copyright
Copyright © 2020 Silveira-Nunes, Durso, Alves de Oliveira, Cunha, Maioli, Vieira, Speziali, Corrêa-Oliveira, Martins-Filho, Teixeira-Carvalho, Franceschi, Rampelli, Turroni, Brigidi and Faria.
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